{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:29:36Z","timestamp":1787023776382,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Green tea extract is a naturally occurring antimicrobial agent, consisting of polyphenols (catechin) with anticariogenic, anti\u2010inflammatory, anticollagenolytic properties. Hence, in the present study, an attempt was made to develop a thermo\u2010reversible sustained\u2010release green tea gel and to study its clinical effects on patients with chronic periodontitis (CP).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Thermo\u2010reversible sustained\u2010release green tea catechin gel was prepared and tested for its in vitro release characteristics. An in vivo controlled, randomized, split\u2010mouth single\u2010evaluator masked study was conducted. Thirty patients with two sites in the contralateral quadrants having probing depths (PDs) of \u22654 mm were selected. Assessment of gingival index (GI), PD, and relative clinical attachment levels (rCALs) was done at baseline and at 4 weeks. Green tea and placebo gels were placed at test and control sites as an adjunct to Phase 1 periodontal therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Comparison of the mean \u00b1 SD GI, PD, and rCAL values within the test group at baseline (1.92 \u00b1 0.24, 4.93 \u00b1 0.58, and 9.97 \u00b1 0.72, respectively) and the end of 4 weeks (0.01 \u00b1 0.04, 2.87 \u00b1 0.51, and 7.87 \u00b1 0.51, respectively) showed high statistical significance (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001). Comparison of mean \u00b1 SD of GI, PD, and rCAL within the control group at baseline (1.95 \u00b1 0.16, 4.77 \u00b1 0.50, and 9.73 \u00b1 0.45, respectively) and the end of 4 weeks (0.16 \u00b1 0.11, 3.8 \u00b1 0.48, and 8.76 \u00b1 0.43, respectively) showed significance with\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001. High significance was observed between the delta of measurements (0 to 4 weeks) of GI, PD, and rCAL between test (1.91 \u00b1 0.20, 2.06 \u00b1 0.07, and 2.1 \u00b1 0.21, respectively) and control (1.79 \u00b1 0.05, 0.97 \u00b1 0.02, and 0.97 \u00b1 0.02, respectively) groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Adjunctive local drug therapy with thermo\u2010reversible green tea gel has shown to reduce pockets and inflammation during the 4 weeks of the clinical trial in patients with CP.\n                  <\/jats:p>","DOI":"10.1902\/jop.2012.120425","type":"journal-article","created":{"date-parts":[[2012,11,3]],"date-time":"2012-11-03T06:46:59Z","timestamp":1351925219000},"page":"1290-1296","source":"Crossref","is-referenced-by-count":63,"title":["Thermo\u2010Reversible Green Tea Catechin Gel for Local Application in Chronic Periodontitis: A 4\u2010Week Clinical Trial"],"prefix":"10.1002","volume":"84","author":[{"given":"Vijay Kumar","family":"Chava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargavi Devi","family":"Vedula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WilsonTG KornmanKS.Fundamentals of Periodontics. 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