{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:32:59Z","timestamp":1760920379210,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Mast cells appear to be associated with human periodontal disease. However, to the best of our knowledge, no studies have evaluated the presence of mast cells in individuals with human immunodeficiency virus (HIV) undergoing highly active antiretroviral therapy (HAART).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Gingival samples were obtained from 50 individuals with and without HIV who presented with chronic gingivitis and periodontitis. Immunohistochemical staining was performed to identify c\u2010kit and tryptase mast cells. Inflammatory infiltrate was evaluated and quantified in the specimens of gingival tissue. In the inflammatory infiltrate subjacent to the pocket epithelium, the densities of the mast cells were calculated. These results were compared between the groups with and without HIV. Correlations could be drawn between the densities of c\u2010kit and tryptase mast cells and the density of inflammatory infiltrate, cluster of differentiation 4 (CD4)\u2010positive and CD8<jats:sup>+<\/jats:sup> T\u2010lymphocyte levels, and viral loads.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Although the individuals with HIV had higher densities of c\u2010kit or tryptase mast cells than those without HIV, both groups presented with chronic gingivitis or periodontitis, and no statistically significant differences could be observed. Both strong and negative correlations could be observed among the inflammatory infiltrate, c\u2010kit, and tryptase in individuals both with and without HIV. Concerning the chronic gingivitis of the individuals with HIV, both strong and positive correlations could be observed between the density of c\u2010kit and CD8<jats:sup>+<\/jats:sup> T\u2010lymphocyte levels.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Individuals with HIV undergoing HAART, compared with individuals without HIV, had no statistically significant differences in mast cell densities in gingival tissue.<\/jats:p>","DOI":"10.1902\/jop.2012.120436","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T22:47:20Z","timestamp":1348526840000},"page":"995-1001","source":"Crossref","is-referenced-by-count":2,"title":["Mast Cells in Periodontal Disease of Individuals With and Without HIV Undergoing Highly Active Antiretroviral Therapy"],"prefix":"10.1002","volume":"84","author":[{"given":"Takeshi Kato","family":"Segundo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna Ribeiro","family":"Souto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Oliveira","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Alves","family":"Mesquita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112103052401"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1996.tb00202.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.6.421"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00197.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-7325.1998.tb03012.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.5.393"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2007.00205.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2006.0211"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01727.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.00019.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.6.915"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1995.tb01180.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12475169"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400304"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4049\/jimmunol.156.4.1490","article-title":"Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells","volume":"156","author":"Malaviya R","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.310401.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300506"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01187-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.4049\/jimmunol.161.10.5647","article-title":"Endogenous superallergen protein Fv induces IL\u20104 secretion from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE","volume":"161","author":"Patella V","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.2.589"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-012-0757-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","unstructured":"HuangS LuF ChenY HuangB LiuM. 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