{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:11:50Z","timestamp":1768677110407,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study is to determine whether periodontal clinical parameters, periodontal bacterial profiles, and inflammatory infiltrate in placental chorionic villi are associated with adverse pregnancy results.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The authors designed an observational case\u2010control study in 244 postpartum females: mothers with preterm\/low\u2013birth weight newborns (n = 91 cases) and mothers with full\u2010term, normal\u2010weight infants (n = 153 controls). Sociodemographic, gynecologic, and periodontal variables were gathered for all participants. Data on placental inflammatory infiltrate in biopsies from 68 cases and 65 controls and the gingival bacterial profile in mothers with periodontitis were gathered, detecting associations with bivariate analyses and constructing a multiple logistic regression model with the number of positive inflammatory cells as the dependent variable.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Periodontal values were significantly worse in cases versus controls. Numbers of leukocyte subsets per square millimeters in maternal and fetal vascular spaces were similar between cases and controls. CD45 in maternal placental space was related to the presence of periodontitis (<jats:italic>P<\/jats:italic> = 0.029) but not to case or control group (<jats:italic>P<\/jats:italic> = 0.264). The anaerobic and commensal bacterial profile in mothers with periodontitis was similar between the groups.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Periodontal disease was more severe and a periodontitis diagnosis more frequent in mothers with preterm or low\u2013birth weight versus normal delivery. No differences in anaerobic or commensal bacterial profile were found between mothers with periodontitis in the two groups. Local placental factors, such as the nature of the inflammatory infiltrate and slightly higher expression of cyclooxygenase\u20102 in the females with these adverse pregnancy outcomes, may be related to a subclinical proinflammatory status that could contribute to triggering premature labor.<\/jats:p>","DOI":"10.1902\/jop.2012.120462","type":"journal-article","created":{"date-parts":[[2012,11,3]],"date-time":"2012-11-03T06:46:59Z","timestamp":1351925219000},"page":"1327-1336","source":"Crossref","is-referenced-by-count":18,"title":["Are Periodontal Bacterial Profiles and Placental Inflammatory Infiltrate in Pregnancy Related to Birth Outcomes?"],"prefix":"10.1002","volume":"84","author":[{"given":"Francisco","family":"Mesa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Pozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Puertas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"O'Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501103120204"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1103"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01755.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.2.161"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","unstructured":"VergnesJN SixouM. Preterm low birth weight and maternal periodontal status: A meta\u2010analysis.Am J Obstet Gynecol2007;196:135.e1\u2010135.e7.","DOI":"10.1016\/j.ajog.2006.09.028"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.09.020"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","unstructured":"PolyzosNP PolyzosIP ZavosA et al. Obstetric outcomes after treatment of periodontal disease during pregnancy: Systematic review and meta\u2010analysis.BMJ2010;341:c7017","DOI":"10.1136\/bmj.c7017"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fdebc0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-011-0036-z"},{"key":"e_1_2_7_11_1","unstructured":"JE Ferguson WF Hansen KF Novak MJ Novak"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01121.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(84)80211-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2272-2279.2004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.09.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.050"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1475-1483.2006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060362"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060368"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062249"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1135-57272001000100003"},{"key":"e_1_2_7_22_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/002203450208100113"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb02067.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/am.24.4.638-644.1972"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.2.509-513.2001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01222.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01366.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01855.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070554"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2008.12.006"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903597"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001749107"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0220125"},{"key":"e_1_2_7_35_1","first-page":"504","article-title":"Relationship between periodontal diseases and ascending bacterial infection with preterm delivery (in Spanish)","volume":"137","author":"Ovalle A","year":"2009","journal-title":"Rev Med Chil"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509335868"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2012.120462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:52:50Z","timestamp":1760878370000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2012.120462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1902\/jop.2012.120462"],"URL":"https:\/\/doi.org\/10.1902\/jop.2012.120462","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}