{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:04:39Z","timestamp":1792512279699,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE012872"],"award-info":[{"award-number":["R01DE012872"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R03DE019805"],"award-info":[{"award-number":["R03DE019805"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of the present study is to examine the association between clinical and radiographic periodontitis measurements during 2 years of periodontal maintenance.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Secondary analyses were performed from a 2\u2010year, double\u2010masked, placebo\u2010controlled, randomized clinical trial evaluating the efficacy and safety of subantimicrobial dose doxycycline (SDD) in 128 postmenopausal osteopenic females with moderate\u2010to\u2010severe chronic periodontitis. Relative clinical attachment level (relative CAL) and probing depth (PD) measurements were made. Posterior vertical bitewings were taken for alveolar bone density (ABD) and alveolar bone height (ABH) measurements. Generalized estimating equations were used to model associations.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> One\u2010year ABD changes and 1\u2010year relative CAL\/PD changes did not predict 2\u2010year ABH changes and ABH\/ABD changes, respectively. Baseline relative CAL and PD were positively associated with baseline ABH loss (<jats:italic>P<\/jats:italic> &lt;0.0001), and baseline PDs were associated with subsequent ABD and ABH loss (<jats:italic>P<\/jats:italic> &lt;0.05 for each). Among placebo (but not SDD) participants, relative CAL changes were associated with concurrent ABD loss (<jats:italic>P<\/jats:italic> = 0.027) when considering 1\u2010 and 2\u2010year changes combined. The odds of ABH loss were higher among sites with concurrent 1\u2010year ABD loss versus no change (odds ratio [OR] = 3.15, <jats:italic>P<\/jats:italic> &lt;0.0001) or concurrent PD increases versus no change (OR = 1.88, <jats:italic>P<\/jats:italic> = 0.0025) when considering 1\u2010 and 2\u2010year changes combined.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In postmenopausal osteopenic females undergoing periodontal maintenance, baseline PD was associated with subsequent ABD and ABH loss. Although no longitudinal change preceded another measurement change, changes in PDs and relative CALs appeared to reflect changes in the underlying alveolar bone over time<jats:italic>.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2012.120484","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T01:42:42Z","timestamp":1354585362000},"page":"1382-1390","source":"Crossref","is-referenced-by-count":10,"title":["The Association Between Clinical and Radiographic Periodontitis Measurements During Periodontal Maintenance"],"prefix":"10.1002","volume":"84","author":[{"given":"Jeffrey B.","family":"Payne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirkka V.","family":"Nummikoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorne M.","family":"Golub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Stoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110187"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1986.57.6.354"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.9.505"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01331.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00290.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1997.tb00576.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.8.829"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01115.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01114.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.8.657"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00474.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.2.103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100207"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb01551.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07694.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb24728.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070623"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050193"},{"key":"e_1_2_7_20_1","unstructured":"United States Department of Health and Human Services.Bone Health and Osteoporosis: A Report of the Surgeon General. Available athttp:\/\/www.surgeongeneral.gov\/library\/bonehealth\/content.html. Accessed May 29 2012."}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2012.120484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:05:29Z","timestamp":1760879129000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2012.120484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1902\/jop.2012.120484"],"URL":"https:\/\/doi.org\/10.1902\/jop.2012.120484","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}