{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:03:59Z","timestamp":1791198239334,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000853","name":"University of Glasgow","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Polycystic ovarian syndrome (PCOS) is a hormonal disorder of females of reproductive age that impacts their oral and systemic health. The aim of this study is to evaluate interleukin\u201017A (IL\u201017A), IL\u201017F, IL\u201017A\/F, and IL\u201017E (IL\u201025) levels in gingival crevicular fluid (GCF), saliva, and serum of non\u2010obese females with PCOS and with either a clinically healthy periodontium or gingivitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010one females with PCOS, 30 females with PCOS and gingivitis, and 12 systemically and periodontally healthy females participated in the study. Clinical periodontal measurements, body mass index, and Ferriman\u2010Gallwey score (FGS) (a measure of hirsutism in females) were recorded. Circulating levels of sex hormones, cortisol, and insulin were also determined. Levels of IL\u201017 cytokines were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The general linear model multivariate analysis, adjusting for age or plaque index, showed that the two groups with PCOS had higher concentrations of IL\u201017A, IL\u201017F, and IL\u201017A\/F in serum and higher levels of IL\u201017A and IL\u201017F in GCF and saliva but lower serum IL\u201017E than systemically healthy females. Levels of IL\u201017E were lowest in females with PCOS and gingivitis who also had the highest FGS. Serum IL\u201017A and IL\u201017F levels correlated positively with FGS and periodontal probing depth (all \u03c1 &gt;0.33; <jats:italic>P<\/jats:italic> &lt;0.005). Serum IL\u201017E showed the reverse relationship and also correlated negatively with IL\u201017A (\u03c1 &gt;\u22120.28; <jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> IL\u201017 levels are altered in non\u2010obese females with PCOS and may influence gingival inflammation. Additional studies are warranted to clarify the relationship between PCOS and gingivitis.<\/jats:p>","DOI":"10.1902\/jop.2013.120483","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T09:39:37Z","timestamp":1358415577000},"page":"1827-1837","source":"Crossref","is-referenced-by-count":55,"title":["Is Interleukin\u201017 Involved in the Interaction Between Polycystic Ovary Syndrome and Gingival Inflammation?"],"prefix":"10.1002","volume":"84","author":[{"given":"\u00d6zg\u00fcn","family":"\u00d6z\u00e7aka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Buduneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu Ozturk","family":"Ceyhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliye","family":"Akcali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Hannah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Nile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Lappin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)30642-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"CarminaE LoboRA. 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