{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:16:46Z","timestamp":1774286206093,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Regenerative periodontal surgery using the combination of enamel matrix derivative (EMD) and natural bone mineral (NBM) with and without addition of platelet\u2010rich plasma (PRP) has been shown to result in substantial clinical improvements, but the long\u2010term effects of this combination are unknown.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The goal of this study was to evaluate the long\u2010term (5\u2010year) outcomes after regenerative surgery of deep intrabony defects with either EMD + NBM + PRP or EMD + NBM. Twenty\u2010four patients were included. In each patient, one intrabony defect was randomly treated with either EMD + NBM + PRP or EMD + NBM. Clinical parameters were evaluated at baseline and 1 and 5 years after treatment. The primary outcome variable was clinical attachment level (CAL).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The sites treated with EMD + NBM + PRP demonstrated a mean CAL change from 10.5 \u00b1 1.6 to 6.0 \u00b1 1.7 mm (<jats:italic>P<\/jats:italic> &lt;0.001) at 1 year and 6.2 \u00b1 1.5 mm (<jats:italic>P<\/jats:italic> &lt;0.001) at 5 years. EMD + NBM\u2013treated defects showed a mean CAL change from 10.6 \u00b1 1.7 to 6.1 \u00b1 1.5 mm (<jats:italic>P<\/jats:italic> &lt;0.001) at 1 year and 6.3 \u00b1 1.4 mm (<jats:italic>P<\/jats:italic> &lt;0.001) at 5 years. At 1 year, a CAL gain of \u22654 mm was measured in 83% (10 of 12) of the defects treated with EMD + NBM + PRP and in 100% (all 12) of the defects treated with EMD + NBM. Compared to baseline, in both groups at 5 years, a CAL gain of \u22654 mm was measured in 75% (nine of 12 in each group) of the defects. Four sites in the EMD + PRP + NBM group lost 1 mm of the CAL gained at 1 year. In the EMD + NBM group, one defect lost 2 mm and four other defects lost 1 mm of the CAL gained at 1 year. No statistically significant differences in any of the investigated parameters were observed between the two groups.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Within their limits, the present results indicate that: 1) the clinical outcomes obtained with both treatments can be maintained up to a period of 5 years; and 2) the use of PRP does not appear to improve the results obtained with EMD + NBM.<\/jats:p>","DOI":"10.1902\/jop.2013.120501","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T09:29:41Z","timestamp":1358414981000},"page":"1546-1555","source":"Crossref","is-referenced-by-count":30,"title":["Five\u2010Year Results Evaluating the Effects of Platelet\u2010Rich Plasma on the Healing of Intrabony Defects Treated With Enamel Matrix Derivative and Natural Bone Mineral"],"prefix":"10.1002","volume":"84","author":[{"given":"Ferenc","family":"D\u00f6ri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Arweiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"H\u00fasz\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Gera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Miron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"471","article-title":"Combination of 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