{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:23:16Z","timestamp":1781817796941,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000853","name":"University of Glasgow","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study is performed to evaluate gingival crevicular fluid (GCF) and serum levels of soluble receptor activator of nuclear factor\u2010\u03baB ligand (sRANKL), interleukin (IL)\u201017A, IL\u201017E, IL\u201017F, IL\u201017A\/F, and osteoprotegerin (OPG) in women with rheumatoid arthritis (RA), osteoporosis (OPR), and those who are systemically healthy (SH), all with periodontal disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> GCF and serum samples were obtained before any periodontal intervention from 17 women with RA, 19 with OPR, and 13 who were SH with periodontitis. Full\u2010mouth clinical periodontal measurements were recorded. sRANKL, OPG, and IL\u201017 levels were determined by enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Clinical periodontal measurements were similar in the three study groups. Although the total amounts of GCF albumin, OPG, IL\u201017A, and IL\u201017A\/F were similar in the study groups, there were statistically significant differences in GCF concentrations of sRANKL, OPG, IL\u201017A, IL\u201017E, IL\u201017F, and IL\u201017A\/F. The sRANKL\/OPG ratios were significantly higher in the RA group than in the OPR and SH groups (<jats:italic>P<\/jats:italic> &lt;0.05). Serum sRANKL, sRANKL\/OPG, and IL\u201017A\/IL\u201017E ratios were significantly higher, whereas OPG concentrations were significantly lower in the RA group compared to other groups (<jats:italic>P<\/jats:italic> &lt;0.05). Serum IL\u201017A concentrations were significantly higher in the RA and OPR groups than in the SH group (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Increased inflammatory mediator levels in patients with RA, despite the long\u2010term use of various anti\u2010inflammatory drugs, suggest that these patients may have a propensity to overproduce these inflammatory mediators.<\/jats:p>","DOI":"10.1902\/jop.2013.120595","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T09:37:48Z","timestamp":1358415468000},"page":"1627-1637","source":"Crossref","is-referenced-by-count":43,"title":["Gingival Crevicular Fluid, Serum Levels of Receptor Activator of Nuclear Factor\u2010\u03baB Ligand, Osteoprotegerin, and Interleukin\u201017 in Patients With Rheumatoid Arthritis and Osteoporosis and With Periodontal 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