{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:34:59Z","timestamp":1780324499778,"version":"3.54.1"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007924","name":"University of Louisville","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study evaluates possible effects of smoking on the following: 1) biochemical content in gingival crevicular fluid (GCF) samples from sites of gingival recession and saliva; and 2) clinical outcomes of coronally advanced flap (CAF) for root coverage.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Eighteen defects in 15 patients were included in each of the smoker and non\u2010smoker groups. Baseline cotinine, basic fibroblast growth factor, vascular endothelial growth factor, platelet\u2010derived growth factor, interleukin (IL)\u20108, IL\u201010, IL\u201012, tumor necrosis factor\u2010\u03b1, matrix metalloproteinase (MMP)\u20108, MMP\u20109, and plasminogen activator inhibitor\u20101 levels were determined in GCF and saliva samples. CAF with microsurgery technique was applied. Plaque index, papilla bleeding index, recession depth (RD), recession width (RW), and root surface area were evaluated at baseline and postoperative months 1, 3, and 6. Probing depth, clinical attachment level (CAL), and keratinized gingival width (KGW) was recorded at baseline and month 6. Percentage of root coverage and complete root coverage were calculated at postoperative months 1, 3, and 6.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All biochemical parameters were similar in the two groups apart from the definite difference in salivary cotinine concentrations (<jats:italic>P<\/jats:italic> = 0.000). Compared with the baseline values, RD, RW, CAL, and root surface area decreased, and KGW increased, with no significant difference between the study groups. CAL gain, percentage of root coverage, and complete root\u2010coverage rates were similar in the study groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Similar baseline biochemical data and comparably high success rates of root coverage with CAF in systemically and periodontally healthy smokers versus non\u2010smokers suggest lack of adverse effects of smoking on clinical outcomes.<\/jats:p>","DOI":"10.1902\/jop.2013.120685","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T13:54:38Z","timestamp":1370008478000},"page":"395-405","source":"Crossref","is-referenced-by-count":24,"title":["The Role of Smoking and Gingival Crevicular Fluid Markers on Coronally Advanced Flap Outcomes"],"prefix":"10.1002","volume":"85","author":[{"given":"Ba\u015fak","family":"Kaval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane 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