{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:02:00Z","timestamp":1792202520666,"version":"4.4.0"},"reference-count":67,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Whether a minimal width of keratinized mucosa (KM) is required to maintain peri\u2010implant tissue health has been a topic of interest. This systematic review and meta\u2010analysis aims to investigate the effect of KM on various peri\u2010implant health\u2010related parameters.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    An electronic search of five databases (from 1965 to October 2012) and a hand search of peer\u2010reviewed journals for relevant articles were performed. Human cross\u2010sectional or longitudinal studies with data on the relationship between the amount of KM around dental implants and various peri\u2010implant parameters, with a follow\u2010up period of at least 6 months, were included.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Eleven studies, seven cross\u2010sectional and four longitudinal, were included. Weighted mean difference (WMD) and confidence interval (CI) were calculated with meta\u2010analyses for each clinical parameter. The results showed statistically significant differences in plaque index (PI) and modified PI (WMD = \u22120.27, 95% CI = \u22120.43 to \u22120.11), modified gingival index (mGI) (WMD = \u22120.48, 95% CI = \u22120.70 to \u22120.27), mucosal recession (MR) (WMD = \u22120.60 mm, 95% CI = \u22120.85 to \u22120.36 mm), and attachment loss (AL) (WMD = \u22120.35 mm, 95% CI = \u22120.65 mm to \u22120.06 mm), all favoring implants with wide KM. However, comparisons of other parameters (bleeding on probing, modified bleeding index, GI, probing depth, and radiographic bone loss) did not reach statistically significant differences. The result of heterogeneity test showed only one parameter (AL,\n                    <jats:italic>P<\/jats:italic>\n                    value for the \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    test = 0.30 and\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    test = 18%) had a low degree of heterogeneity among analyzed studies; meta\u2010analyses of other parameters presented moderate\u2010to\u2010high degree of heterogeneity. Limitations of the present review include limited number of selected studies (n = 11), existence of heterogeneity and publication bias, and only English\u2010written articles searched.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Based on current available evidence, a lack of adequate KM around endosseous dental implants is associated with more plaque accumulation, tissue inflammation, MR, and AL.\n                  <\/jats:p>","DOI":"10.1902\/jop.2013.120688","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T13:38:57Z","timestamp":1362145137000},"page":"1755-1767","source":"Crossref","is-referenced-by-count":397,"title":["The Significance of Keratinized Mucosa on Implant Health: A Systematic Review"],"prefix":"10.1002","volume":"84","author":[{"given":"Guo\u2010Hao","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsun\u2010Liang","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.10.623"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb02273.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb01974.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.6.349"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1985.tb00938.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb02159.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb02208.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb00964.x"},{"key":"e_1_2_7_10_1","unstructured":"LindheJ EcheverriaJ. 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