{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:16:18Z","timestamp":1788347778869,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE019456"],"award-info":[{"award-number":["R01DE019456"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Matrix metalloproteinases (MMPs) are a family of host\u2010derived proteinases reported to mediate multiple functions associated with periodontal breakdown and inflammation. High MMP levels in African\u2010American children with localized aggressive periodontitis (LAgP) have been reported previously by the present authors. However, little is known about MMP reductions in gingival crevicular fluid (GCF) after therapy. This study aims to evaluate MMP levels in the GCF after treatment of LAgP and to correlate these levels with clinical response.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> GCF samples were collected from 29 African\u2010American individuals diagnosed with LAgP. GCF was collected from one diseased site (probing depth [PD] &gt;4 mm, bleeding on probing [BOP], and clinical attachment level \u22652 mm) and one healthy site (PD \u22643 mm, no BOP) from each individual at baseline and 3 and 6 months after periodontal treatment, which consisted of full\u2010mouth scaling and root planing (SRP) and systemic antibiotics. The volume of GCF was controlled using a calibrated gingival fluid meter, and levels of MMP\u20101, MMP\u20102, MMP\u20103, MMP\u20108, MMP\u20109, MMP\u201012, and MMP\u201013 were assessed using fluorometric kits.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> MMP\u20101, MMP\u20108, MMP\u20109, MMP\u201012, and MMP\u201013 levels were reduced significantly up to 6 months, comparable to healthy sites at the same point. Significant correlations were noted between MMP\u20102, MMP\u20103, MMP\u20108, MMP\u20109, MMP\u201012, and MMP\u201013 levels and percentage of sites with PD &gt;4 mm. MMP\u20103, MMP\u201012, and MMP\u201013 levels also correlated with mean PD of affected sites.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Treatment of LAgP with SRP and systemic antibiotics was effective in reducing local levels of specific MMPs in African\u2010American individuals, which correlated positively with some clinical parameters.<\/jats:p>","DOI":"10.1902\/jop.2013.130002","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T11:13:13Z","timestamp":1364469193000},"page":"1801-1808","source":"Crossref","is-referenced-by-count":64,"title":["Periodontal Treatment Reduces Matrix Metalloproteinase Levels in Localized Aggressive Periodontitis"],"prefix":"10.1002","volume":"84","author":[{"given":"Patricia 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