{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T22:53:13Z","timestamp":1766011993191,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007417","name":"Paulon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007650","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riliitto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007650","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Initiation and progression of periodontitis correlates with increased quantities of periodontitis\u2010associated bacteria in periodontal biofilms. In the present study, the aim is to measure <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic> amounts in saliva and their antibody (immunoglobulin [Ig]A and IgG) levels in serum and evaluate their diagnostic abilities, together or alone, in chronic periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study population comprised 230 Finnish dentate adults: 84 with generalized chronic periodontitis (GCP), 65 with localized chronic periodontitis (LCP), and 81 controls without periodontitis. General and oral health information was obtained by questionnaires, interviews, and clinical and radiographic examinations. Salivary and serum samples were analyzed by quantitative single copy gene\u2013based real\u2010time polymerase chain reaction and multiserotype enzyme\u2010linked immunosorbent assay, respectively.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Pathogen carriers suffered mostly from GCP and seldom from LCP. <jats:italic>A. actinomycetemcomitans<\/jats:italic> and <jats:italic>P. gingivalis<\/jats:italic> quantities in saliva were strongly associated with corresponding serum IgA and IgG values (<jats:italic>P<\/jats:italic> &lt;0.001) and with severity of disease (<jats:italic>P<\/jats:italic> &lt;0.001). <jats:italic>P. gingivalis<\/jats:italic> exhibited more straightforward associations among salivary bacterial burdens, corresponding antibody formation, and periodontitis severity than <jats:italic>A. actinomycetemcomitans<\/jats:italic>. The combination of information on age, sex, smoking, and <jats:italic>P. gingivalis<\/jats:italic> results provided an area under the curve of 0.817 (95% confidence interval 0.76 to 0.87, <jats:italic>P<\/jats:italic> &lt;0.001) for GCP.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The combination of saliva <jats:italic>P. gingivalis<\/jats:italic> quantity with pathogen\u2010specific host response may be used to diagnose periodontitis with high accuracy.<\/jats:p>","DOI":"10.1902\/jop.2013.130030","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T06:26:41Z","timestamp":1367908001000},"page":"123-131","source":"Crossref","is-referenced-by-count":32,"title":["Combining Salivary Pathogen and Serum Antibody Levels Improves Their Diagnostic Ability in Detection of Periodontitis"],"prefix":"10.1002","volume":"85","author":[{"given":"John M.","family":"Liljestrand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulvi K.","family":"Gursoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kati","family":"Hyv\u00e4rinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna L.","family":"Suominen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eija","family":"K\u00f6n\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirkko J.","family":"Pussinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1111\/j.1600-0757.1999.tb00155.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1902\/jop.2011.110116"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.2174\/092986707781745604"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1016\/j.oraloncology.2012.01.021"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1155\/2011\/621484"},{"unstructured":"Suominen\u2010Taipale L Nordblad A Vehkalahti M Aromaa A eds. 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