{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:27:22Z","timestamp":1789943242484,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Soluble triggering receptor expressed on myeloid cells 1 (sTREM\u20101) belongs to the immunoglobulin superfamily and is involved in amplification of the inflammatory response to bacterial infection. This cross\u2010sectional study aims to investigate the levels of sTREM\u20101 in gingival crevicular fluid (GCF) of individuals without periodontitis and with chronic periodontitis (CP) or generalized aggressive periodontitis (GAgP) and their association with the levels of key periodontal pathogens in subgingival plaque.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> GCF and subgingival plaque samples were obtained from healthy sites of participants without periodontitis (n = 20) and periodontitis sites of patients with CP (n = 22) and GAgP (n = 20). sTREM\u20101 levels in GCF were measured by enzyme\u2010linked immunosorbent assay. <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Treponema denticola<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic>, and <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> levels in subgingival plaque were analyzed by quantitative real\u2010time polymerase chain reaction.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> sTREM\u20101 levels in GCF were higher in CP and GAgP than healthy sites by 3.6\u2010 and 4.4\u2010fold, respectively, with no significant differences between the two forms of periodontitis. Moreover, sTREM\u20101 levels in GCF were positively correlated with site\u2010specific clinical periodontal parameters and levels of <jats:italic>P. gingivalis<\/jats:italic>, <jats:italic>T. denticola<\/jats:italic>, and <jats:italic>T. forsythia<\/jats:italic>, but not <jats:italic>A. actinomycetemcomitans<\/jats:italic>, in subgingival plaque.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Increased GCF levels of sTREM\u20101 at diseased sites and their positive correlation with clinical and microbiologic parameters strengthen the association of this inflammatory marker with periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2013.130144","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T15:22:57Z","timestamp":1368112977000},"page":"204-210","source":"Crossref","is-referenced-by-count":45,"title":["Soluble Triggering Receptor Expressed on Myeloid Cells 1 (sTREM\u20101) in Gingival Crevicular Fluid: Association With Clinical and Microbiologic Parameters"],"prefix":"10.1002","volume":"85","author":[{"given":"Georgios N.","family":"Belibasakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veli\u2010\u00d6zgen","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnur","family":"Emingil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3812"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/35074114"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031544"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040708"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-933671"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/506950"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.089557"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.4991"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/374754"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-157"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31817b8824"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0514-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00331.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.09.012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2009.06.006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2012.02579.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512470691"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6_part2.610"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000408303"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12034"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.30.9.2225-2229.1992"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00483.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2.3.181"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080480"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01534.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01813.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110060"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2012.00982.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.4065"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411010120030101"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00377.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075784"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2013.130144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:18:58Z","timestamp":1760865538000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2013.130144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1902\/jop.2013.130144"],"URL":"https:\/\/doi.org\/10.1902\/jop.2013.130144","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}