{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T01:50:22Z","timestamp":1783561822745,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["HUCH\u2010EVO TI020Y0002"],"award-info":[{"award-number":["HUCH\u2010EVO TI020Y0002"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["TYH 5306"],"award-info":[{"award-number":["TYH 5306"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["TYH 6104"],"award-info":[{"award-number":["TYH 6104"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Molecular biomarkers are needed for diagnostic use in periodontal diseases. The aim of this study is to explore different gingival crevicular fluid (GCF) matrix metalloproteinase\u20108 (MMP\u20108) patterns in smokers and non\u2010smokers with chronic periodontitis (CP) and test the utility of baseline GCF MMP\u20108 levels in predicting categorically assessed treatment outcomes.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study population comprised 15 patients with CP (five non\u2010smokers and 10 smokers). GCF sampling of five to seven periodontal sites per patient was done at baseline, post\u2010treatment, and bimonthly during the maintenance period from 8 to 12 months. GCF MMP\u20108 levels were measured with an immunofluorometric assay. MMP\u20108 response patterns were explored by cluster analysis. The ability of baseline MMP\u20108 levels to predict categorical treatment outcomes was analyzed with receiver operating characteristic curves.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> GCF MMP\u20108 response patterns could be clustered into two different site profiles among both smokers and non\u2010smokers. Smoker site profiles 1 and 2 had significantly different clinical attachment level and gingival recession changes by the end of the maintenance period. In smoker sites, baseline MMP\u20108 levels significantly predicted the categorical treatment outcome.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Baseline GCF MMP\u20108 levels strongly predict how MMP\u20108 levels behave during the maintenance period. In smoker sites, high baseline MMP\u20108 levels indicate weak treatment response.<\/jats:p>","DOI":"10.1902\/jop.2013.130156","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T15:22:57Z","timestamp":1368112977000},"page":"250-260","source":"Crossref","is-referenced-by-count":45,"title":["Gingival Crevicular Fluid Matrix Metalloproteinase\u20108 Levels Predict Treatment Outcome Among Smokers With Chronic Periodontitis"],"prefix":"10.1002","volume":"85","author":[{"given":"Jussi M.","family":"Leppilahti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko 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