{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:01:56Z","timestamp":1777503716364,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["(DMR\u2010102\u2010014 and DMR\u2010102\u2010023)"],"award-info":[{"award-number":["(DMR\u2010102\u2010014 and DMR\u2010102\u2010023)"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study is to determine whether patients with a non\u2010apnea sleep disorder (NA\u2010SD) and comorbidity have an increased risk of periodontal disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Patients newly diagnosed with NA\u2010SDs in 1997 to 2010 were identified as the study cohort from the Taiwan National Health Insurance database. For each patient with NA\u2010SD, two matched controls without sleep disorders were randomly selected for comparison.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The overall incidence rate ratio of severe periodontal diseases was 39% higher in the NA\u2010SD cohort than in the comparison cohort (7.93 versus 5.69 per 1,000 person\u2010years), with an adjusted hazard ratio (HR) of 1.36 (95% confidence interval [CI]: 1.30 to 1.43). The effect of NA\u2010SD on the risk of severe periodontal diseases was higher in young and middle\u2010aged patients compared with patients &gt;65 years of age (&lt;35 years of age, HR: 1.13, 95% CI: 1.04 to 1.24; 35 to 49 years of age, HR: 1.73, 95% CI: 1.61 to 1.86; 50 to 64 years of age, HR: 1.69, 95% CI: 1.58 to 1.81; \u226565, HR: [reference] 1.0).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> NA\u2010SD might increase the risk of periodontal disease.<\/jats:p>","DOI":"10.1902\/jop.2013.130284","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T07:28:31Z","timestamp":1380007711000},"source":"Crossref","is-referenced-by-count":25,"title":["Non\u2010Apnea Sleep Disorder Increases the Risk of Periodontal Disease: A Retrospective Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"85","author":[{"given":"Chun\u2010Feng","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Chia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Ming","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan\u2010Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Jung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Hung","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01121.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242012000700007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2001.tb00267.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.134005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","unstructured":"Mealey BL Oates TW; American Academy of Periodontology. 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