{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:04:07Z","timestamp":1791151447384,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21DE018757"],"award-info":[{"award-number":["1R21DE018757"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5TL1RR024984"],"award-info":[{"award-number":["5TL1RR024984"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5UL1RR024982"],"award-info":[{"award-number":["5UL1RR024982"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007904","name":"Texas A and M University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007904","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Previous research has indicated that salivary interleukin (IL)\u20106 and IL\u20108 are potential biomarkers for oral squamous cell carcinoma (OSCC). However, their levels have been found to be significantly elevated in patients with chronic periodontitis (CP) or oral lichen planus (OLP). The data also showed wide variations in levels among the different studies, and no standardization procedure was ever performed. Therefore, the objective of this study is to determine whether CP or OLP confounds the use of IL\u20106 or IL\u20108 for OSCC detection.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Saliva samples were collected from five groups: OSCC before treatment (n = 18); CP (n = 21); disease\u2010active OLP (n = 21); disease\u2010inactive OLP (n = 20); and healthy controls (n = 21). IL\u20106 and IL\u20108 concentrations (determined by enzyme\u2010linked immunosorbent assays) were compared, using total salivary protein\u2013standardized levels to validate the data. The Kruskal\u2013Wallis test (\u03b1 = 0.05) followed by pairwise Mann\u2013Whitney <jats:italic>U<\/jats:italic> (post hoc) tests with Bonferroni adjustments (\u03b1 = 0.00625) were used for statistical analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Salivary IL\u20106 levels were significantly higher in patients with OSCC than in patients with CP (<jats:italic>P<\/jats:italic> &lt;0.001), disease\u2010active OLP (<jats:italic>P<\/jats:italic> = 0.001), disease\u2010inactive OLP (<jats:italic>P<\/jats:italic> &lt;0.001), and healthy controls (<jats:italic>P<\/jats:italic> &lt;0.001). Salivary IL\u20108 levels were significantly higher in patients with OSCC than in patients with CP (<jats:italic>P<\/jats:italic> &lt;0.001), but only marginally significantly higher than in healthy controls (<jats:italic>P<\/jats:italic> = 0.014). Statistical results of standardized IL\u20106 and IL\u20108 levels were consistent with the non\u2010standardized levels in all pairs except one.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Salivary IL\u20106 may be a useful biomarker in the detection of OSCC, unconfounded by CP or OLP.<\/jats:p>","DOI":"10.1902\/jop.2013.130320","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T08:35:40Z","timestamp":1382517340000},"page":"956-965","source":"Crossref","is-referenced-by-count":77,"title":["Salivary Interleukin\u20106 and \u20108 in Patients With Oral Cancer and Patients With Chronic Oral Inflammatory Diseases"],"prefix":"10.1002","volume":"85","author":[{"given":"Yi\u2010Shing","family":"Lisa Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi 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