{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:19:05Z","timestamp":1782123545297,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The cytokine profile in unstimulated whole saliva (UWS) of patients with prediabetes and chronic periodontitis (CP) remains uninvestigated. The aim of this study is to assess interleukin (IL)\u20106 and matrix metalloproteinase (MMP)\u20108 levels in UWS of patients with CP with and without prediabetes.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Eighty\u2010eight males (aged 39 to 51 years) were divided into three groups: group 1: 28 patients with CP and prediabetes; group 2: 30 patients with CP and without prediabetes; and group 3: 30 controls. Fasting blood glucose (FBG) and hemoglobin A1c (HbA1c) levels, periodontal parameters (plaque index, bleeding on probing, probing depth, attachment loss, and marginal bone loss), and number of missing teeth were recorded. UWS samples were collected, and UWS flow rate (UWSFR) was measured. IL\u20106 and MMP\u20108 were measured in UWS using enzyme\u2010linked immunosorbent assay. <jats:italic>P<\/jats:italic> values &lt;0.05 were considered statistically significant.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Mean FBG and HbA1c levels were significantly higher in group 1 (119.3 \u00b1 3.1 mg\/dL and 6.1% \u00b1 0.2%) than group 2 (80.1 \u00b1 3.5 mg\/dL and 4.8% \u00b1 0.5%; <jats:italic>P<\/jats:italic> &lt;0.001) and group 3 (75.3 \u00b1 2.2 mg\/dL and 4.3% \u00b1 0.2%; <jats:italic>P<\/jats:italic> &lt;0.05). UWSFR was significantly higher in groups 2 (0.53 \u00b1 0.1 mL\/minute; <jats:italic>P<\/jats:italic> &lt;0.05) and 3 (0.51 \u00b1 0.1 mL\/minute; <jats:italic>P<\/jats:italic> &lt;0.01) than group 1 (0.33 \u00b1 0.05 mL\/minute). Periodontal parameters were worse in group 1 (<jats:italic>P<\/jats:italic> &lt;0.05) and group 2 (<jats:italic>P<\/jats:italic> &lt;0.05) than group 3. There was no difference in periodontal parameters, numbers of missing teeth, or salivary IL\u20106 and MMP\u20108 levels between patients in groups 1 and 2.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Salivary IL\u20106 and MMP\u20108 levels are elevated in patients with CP with and without prediabetes.<\/jats:p>","DOI":"10.1902\/jop.2013.130514","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T14:52:04Z","timestamp":1383144724000},"source":"Crossref","is-referenced-by-count":38,"title":["Whole Salivary Interleukin\u20106 and Matrix Metalloproteinase\u20108 Levels in Patients With Chronic Periodontitis With and Without Prediabetes"],"prefix":"10.1002","volume":"85","author":[{"given":"Fawad","family":"Javed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hameeda Bashir","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abid","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crawford","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31823650a7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31824d5337"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120390"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.04.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00883.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070186"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31827333fb"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110207"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-9-12"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2008.01895.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061356"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12038"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01866.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300209"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18356.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080070"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090510"},{"key":"e_1_2_7_19_1","first-page":"S11","article-title":"Interleukin\u20106 \u2014 A key mediator of systemic and local symptoms in rheumatoid arthritis","volume":"65","author":"Cronstein BN","year":"2007","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.050451"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-S011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130008"},{"key":"e_1_2_7_23_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_7_24_1","first-page":"107","article-title":"Gingival sulcus bleeding \u2014 A leading symptom in initial gingivitis","volume":"15","author":"M\u00fchlemann HR","year":"1971","journal-title":"Helv Odontol Acta"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb02271.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.37"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000155734.34652.6c"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.125"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02106.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/nhs.12055"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9771-5"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350802286725"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2013.130514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:16:41Z","timestamp":1760883401000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2013.130514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1902\/jop.2013.130514"],"URL":"https:\/\/doi.org\/10.1902\/jop.2013.130514","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}