{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:25:14Z","timestamp":1783797914692,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of this study is to compare clinical outcomes in the treatment of deep non\u2010contained intrabony defects (i.e., with \u226570% 1\u2010wall component and a residual 2\u2010 to 3\u2010wall component in the most apical part) using deproteinized bovine bone mineral (DBBM) combined with either enamel matrix protein derivative (EMD) or collagen membrane (CM).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty patients with multiple intrabony defects were enrolled. Only one non\u2010contained defect per patient with an intrabony depth \u22653 mm located in the interproximal area of single\u2010 and multirooted teeth was randomly assigned to the treatment with either EMD + DBBM (test: n = 20) or CM + DBBM (control: n = 20). At baseline and after 12 months, clinical parameters including probing depth (PD) and clinical attachment level (CAL) were recorded. The primary outcome variable was the change in CAL between baseline and 12 months.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At baseline, the intrabony component of the defects amounted to 6.1 \u00b1 1.9 mm for EMD + DBBM and 6.0 \u00b1 1.9 mm for CM + DBBM sites (<jats:italic>P<\/jats:italic> = 0.81). The mean CAL gain at sites treated with EMD + DBBM was not statistically significantly different (<jats:italic>P<\/jats:italic> = 0.82) compared with CM + DBBM (3.8 \u00b1 1.5 versus 3.7 \u00b1 1.2 mm). No statistically significant difference (<jats:italic>P<\/jats:italic> = 0.62) was observed comparing the frequency of CAL gain \u22654 mm between EMD + DBBM (60%) and CM + DBBM (50%) or comparing the frequency of residual PD \u22656 mm between EMD + DBBM (5%) and CM + DBBM (15%) (<jats:italic>P<\/jats:italic> = 0.21).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Within the limitations of the present study, regenerative therapy using either EMD + DBBM or CM + DBBM yielded comparable clinical outcomes in deep non\u2010contained intrabony defects after 12 months.<\/jats:p>","DOI":"10.1902\/jop.2014.130420","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T09:38:09Z","timestamp":1400233089000},"page":"1342-1350","source":"Crossref","is-referenced-by-count":46,"title":["Clinical Outcomes Following Regenerative Therapy of Non\u2010Contained Intrabony Defects Using a Deproteinized Bovine Bone Mineral Combined With Either Enamel Matrix Derivative 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