{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:14:21Z","timestamp":1790486061169,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Treatment of concomitant endodontic\u2010periodontal lesions remains a challenge in clinical practice and requires effective endodontic and regenerative periodontal therapy. Among other factors, cross seeding and recolonization of flora may affect the outcome of periodontal therapy. Intracanal medicaments have been shown to exert antimicrobial activity on the external root surface, and local delivery of antimicrobials has been suggested to be a complementary approach in the management of periodontitis. Therefore, the objective of this study is to determine the influence of chlorhexidine (CHX) intracanal medicament on the clinical outcomes of therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010one patients were divided into two treatment groups: 1) open flap debridement (OFD) in endodontically treated teeth (control); and 2) OFD in endodontically treated teeth with CHX placed in the coronal space (test). The clinical variables evaluated were probing depth (PD), clinical attachment level (CAL), and percentage of sites with PD \u22655 mm. Reevaluation was performed at 3 and 6 months post\u2010surgery.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both treatments resulted in improvement in all the clinical variables evaluated. Postoperative measurements from test and control groups showed reductions in mean PD of 2.22 \u00b1 1.27 and 0.91 \u00b1 0.81 mm, mean CAL gains of 2.16 \u00b1 1.12 and 0.60 \u00b1 0.93 mm, and 43.33% \u00b1 31.37% and 17.71% \u00b1 14.23% reduction in sites with PD \u22655 mm. Significantly more PD reduction, CAL gain, and percentage reduction in sites with PD \u22655 mm were observed in the test group at 6 months (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> CHX may be used as an effective intracanal medicament for promoting periodontal healing in concomitant endodontic\u2010periodontal lesions.<\/jats:p>","DOI":"10.1902\/jop.2014.130430","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T09:38:09Z","timestamp":1400233089000},"page":"1019-1026","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of Efficacy of Chlorhexidine Intracanal Medicament on the Periodontal Healing of Concomitant Endodontic\u2010Periodontal Lesions Without Communication: An Interventional Study"],"prefix":"10.1002","volume":"85","author":[{"given":"Jyoti","family":"Raheja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigyasa","family":"Duhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01145.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81115-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90139-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1988.tb00294.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1990.tb00378.x"},{"key":"e_1_2_7_7_1","first-page":"85","article-title":"Development of periapical lesions","volume":"17","author":"Jansson L","year":"1993","journal-title":"Swed Dent J"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00325.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.10.947"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00746.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00811.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00254.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2008.09.009"},{"key":"e_1_2_7_14_1","first-page":"427","article-title":"Early antimicrobial activity of intracanal medications on the external root surface of periodontally compromised teeth","volume":"41","author":"Silva MR","year":"2010","journal-title":"Quintessence Int"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242004000100011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00482.x"},{"key":"e_1_2_7_17_1","first-page":"13","article-title":"Local delivery of antimicrobials: A new era in the treatment of adult periodontitis","volume":"20","author":"Killoy WJ","year":"1999","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_18_1","first-page":"4","article-title":"The supplemental use of antibiotics in periodontal therapy","volume":"20","author":"Walker C","year":"1999","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00119.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2003.09.022"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00354.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.12.1199"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.9.577"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1997.0094"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290801.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1995.0210"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(87)90319-7"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.4.222"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00215.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(84)90377-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1994.tb00534.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00634.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.07.010"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00694.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4477.2006.00033.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200006000-00001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1998.tb00835.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1990.tb00384.x"},{"key":"e_1_2_7_39_1","first-page":"422","article-title":"Further in vivo studies on the plaque\u2010inhibiting effect of chlorhexidine and its binding mechanisms","volume":"98","author":"Waaler SM","year":"1990","journal-title":"Scand J Dent Res"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1964.tb07384.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00547.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012897.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00442.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02515.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2001.280806.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280104.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00994.x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00022.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2014.130430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:55:52Z","timestamp":1760874952000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2014.130430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1902\/jop.2014.130430"],"URL":"https:\/\/doi.org\/10.1902\/jop.2014.130430","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}