{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:04:54Z","timestamp":1789995894642,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/51218\u20108"],"award-info":[{"award-number":["2010\/51218\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study investigates the effect of photodynamic therapy (PDT) as monotherapy during supportive periodontal therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A split\u2010mouth, randomized controlled trial was conducted in patients with chronic periodontitis (N = 22) presenting at least three residual pockets (probing depth [PD] \u22655 mm with bleeding on probing [BOP]). The selected sites randomly received the following: 1) PDT; 2) photosensitizer (PS); or 3) scaling and root planing (SRP). At baseline and 3 and 6 months, clinical, microbiologic (real\u2010time polymerase chain reaction analyses), cytokine pattern (multiplexed bead immunoassay), and patient\u2010centered (regarding morbidity) evaluations were performed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All therapies promoted similar improvements in clinical parameters throughout the study (<jats:italic>P<\/jats:italic> &lt;0.05), except that BOP was not reduced in the PS protocol (<jats:italic>P<\/jats:italic> &gt;0.05). Lower levels of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> were observed in the PDT and SRP protocols at 3 months when compared with the PS protocol (<jats:italic>P<\/jats:italic> &lt;0.05). An inferior frequency detection of <jats:italic>Porphyromonas gingivalis<\/jats:italic> was observed in the PDT protocol at 3 and 6 months and in the SRP protocol at 6 months from baseline (<jats:italic>P<\/jats:italic> &lt;0.05). In addition, PDT protocol presented inferior frequency of <jats:italic>P. gingivalis<\/jats:italic> at 3 months when compared with the other therapies (<jats:italic>P<\/jats:italic> &lt;0.05). Only patients in the PDT protocol exhibited augmented levels of anti\u2010inflammatory interleukin (IL)\u20104 and reduced proinflammatory IL\u20101\u03b2 and IL\u20106 throughout the study (<jats:italic>P<\/jats:italic> &lt;0.05). Intergroup analyses showed reduced IL\u201010 and increased interferon\u2010\u03b3 and IL\u20101\u03b2 levels in the PS protocol when compared with the other therapies during follow\u2010ups (<jats:italic>P<\/jats:italic> &lt;0.05). No differences in morbidity were observed between the therapies (<jats:italic>P<\/jats:italic> &gt;0.05), although the need for anesthesia was higher in SRP\u2010treated sites (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> PDT as an exclusive therapy may be considered a non\u2010invasive alternative for treating residual pockets, offering advantages in the modulation of cytokines.<\/jats:p>","DOI":"10.1902\/jop.2014.130559","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T06:57:35Z","timestamp":1392965855000},"source":"Crossref","is-referenced-by-count":78,"title":["Photodynamic Therapy During Supportive Periodontal Care: Clinical, Microbiologic, Immunoinflammatory, and Patient\u2010Centered Performance in a Split\u2010Mouth Randomized Clinical Trial"],"prefix":"10.1002","volume":"85","author":[{"given":"Maria 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