{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:45:11Z","timestamp":1791189911479,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> YKL\u201040, a new acute\u2010phase protein, is shown to be elevated in inflammatory diseases, such as rheumatoid arthritis, type 2 diabetes mellitus, and coronary artery diseases. However, there is no data indicating a relationship between YKL\u201040 and periodontal disease. Interleukin\u20106 (IL\u20106) is the major regulator of acute\u2010phase protein synthesis and one of the most studied inflammatory markers in periodontal disease. The purpose of the present study is to evaluate YKL\u201040 and IL\u20106 levels in gingival crevicular fluid (GCF) and serum of patients with periodontal disease and healthy individuals.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Periodontally healthy individuals (n = 15), patients with gingivitis (n = 15), and patients with severe chronic periodontitis (CP) (n = 15) without any systemic disease were included in the study. Clinical measurements were recorded; GCF and blood samples were obtained from each participant. GCF and serum YKL\u201040 and IL\u20106 levels were analyzed by enzyme\u2010linked immunosorbent assay. Statistical analysis was performed by parametric and non\u2010parametric tests.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Total amounts of YKL\u201040 and IL\u20106 in GCF as well as serum YKL\u201040 and IL\u20106 levels were significantly higher in patients with gingivitis and CP compared with healthy controls (<jats:italic>P<\/jats:italic> &lt;0.01). YKL\u201040 levels in GCF and serum as well as serum IL\u20106 levels were significantly higher in patients with CP compared with patients with gingivitis (<jats:italic>P<\/jats:italic> &lt;0.01).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> YKL\u201040 levels in GCF as well as serum YKL\u201040 and IL\u20106 levels increased from gingivitis to periodontitis. Within the limits of the present study, the YKL\u201040 molecule might be a potential novel inflammatory marker of periodontal disease.<\/jats:p>","DOI":"10.1902\/jop.2014.130631","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T15:44:24Z","timestamp":1395071064000},"page":"1240-1246","source":"Crossref","is-referenced-by-count":36,"title":["Analysis of YKL\u201040 Acute\u2010Phase Protein and Interleukin\u20106 Levels in Periodontal Disease"],"prefix":"10.1002","volume":"85","author":[{"given":"Zeynep Pinar","family":"Keles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonca Cayir","family":"Keles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahattin","family":"Avci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu 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