{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:34:21Z","timestamp":1760920461859,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["10ZR1425900"],"award-info":[{"award-number":["10ZR1425900"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Chronic periodontitis (CP) is a multifactorial complex periodontal disease involving immune response, inflammation, alveolar bone resorption, and attachment loss. Colony stimulating factor\u20101 (<jats:italic>CSF\u20101<\/jats:italic>) controls the production, differentiation, and function of macrophages and plays a vital role in the innate immune response to the external microbial infections, suggesting the potential role of <jats:italic>CSF\u20101<\/jats:italic> in the pathogenesis of periodontitis. The objective of this study is to determine the association of single nucleotide polymorphisms (SNPs) rs333967, rs2297706, and rs1058885 with CP in the Han Chinese population.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Genomic DNA was isolated from buccal epithelial cells obtained from unrelated Chinese participants (440 patients with CP and 324 controls). The SNPs were genotyped by a matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight mass spectrometry method.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Three previously identified SNPs were genotyped in Han Chinese with Shanghai origin, but none of them was statistically significantly associated with CP. However, a T\u2010C\u2010G haplotype in male participants showed an observed <jats:italic>P<\/jats:italic> value of 4.52<jats:sup>E\u201008<\/jats:sup>, with an odds ratio of 0.092.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> None of the individual SNPs among rs333967, rs2297706, and rs1058885 in <jats:italic>CSF\u20101<\/jats:italic> was found statistically significantly associated with CP in the Han Chinese population with Shanghai origin, whereas a haplotype T\u2010C\u2010G showed an observed statistically significant association with decreased risk of CP susceptibility in males.<\/jats:p>","DOI":"10.1902\/jop.2014.130688","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T08:50:54Z","timestamp":1393923054000},"source":"Crossref","is-referenced-by-count":4,"title":["The Association of <i>CSF\u20101<\/i> Gene Polymorphism With Chronic Periodontitis in the Han Chinese 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