{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:41:55Z","timestamp":1790023315221,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold>: The standard of care for increasing keratinized tissue (KT) and vestibular area is an autogenous free gingival graft (FGG) and vestibuloplasty; however, there is morbidity associated with the harvest of autogenous tissue, and supply is limited. The purpose of this study is to determine if a xenogeneic collagen matrix (CM) might be as effective as FGG.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This study is a single\u2010masked, randomized, controlled, split\u2010mouth study of 30 patients with insufficient zones of KT (&lt;2 mm). It uses a within\u2010patient treatment\u2010comparison design to establish non\u2010inferiority of the test (CM) versus control (FGG) therapy. The primary efficacy endpoint was change in KT width (\u2206KT) from surgery to 6 months post\u2010surgery. Secondary endpoints included traditional periodontal measures, such as clinical attachment level, recession, and bleeding on probing. Patient\u2010reported pain, discomfort, and esthetic satisfaction were also recorded. Biopsies were obtained at 6 months.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Surgery and postoperative sequelae were uneventful, with normal healing observed at both test and control sites. The primary outcome, \u2206KT width at 6 months, did not establish non\u2010inferiority of CM compared to FGG (<jats:italic>P<\/jats:italic> = 0.9992), with the FGG sites averaging 1.5 mm more KT width than CM sites. However, the amount of new KT generated for both therapies averaged \u22652 mm. Secondary outcomes were not significantly different between test and control sites. All site biopsies appeared as normal mucoperiosteum with keratinized epithelium. CM sites achieved better texture and color matches, and more than two\u2010thirds of patients preferred the appearance of their CM sites.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> With the proviso of sufficient KT (\u22482 mm in width) and study goals of lower morbidity, unlimited supply, and patient satisfaction, CM appears to be a suitable substitute for FGG in vestibuloplasty procedures designed to increase KT around teeth.<\/jats:p>","DOI":"10.1902\/jop.2014.130692","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T10:54:47Z","timestamp":1394016887000},"page":"1333-1341","source":"Crossref","is-referenced-by-count":51,"title":["Randomized, Controlled Clinical Trial to Evaluate a Xenogeneic Collagen Matrix as an Alternative to Free Gingival Grafting for Oral Soft Tissue Augmentation"],"prefix":"10.1002","volume":"85","author":[{"given":"Michael K.","family":"McGuire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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