{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:03:59Z","timestamp":1791198239292,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Recently, some studies have revealed the effect of polycystic ovary syndrome (PCOS) on gingival inflammation. This cross\u2010sectional study attempts to assess the periodontal status and systemic inflammation of women receiving medical treatment for PCOS and women newly diagnosed with PCOS.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 126 participants comprising 41 newly diagnosed patients with PCOS (PCOS\u2010N), 45 patients with PCOS on medical treatment (PCOS\u2010MT), and 40 systemically healthy controls (control group [CG]) were examined. Periodontal parameters, anthropometric parameters, and serum levels of high\u2010sensitivity C\u2010reactive protein (hsCRP) were recorded.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Women with newly diagnosed PCOS had increased sites with bleeding on probing (BOP), probing depth, clinical attachment level (CAL), waist circumference (WC), hsCRP, and prevalence of periodontitis compared with control and PCOS\u2010MT groups (<jats:italic>P<\/jats:italic> \u22640.05). On partial correlation analysis after controlling for confounders, BOP and CAL correlated positively and significantly with hsCRP (<jats:italic>P<\/jats:italic> = 0.01 and <jats:italic>P<\/jats:italic> = 0.005). Multivariate linear regression analysis revealed that BOP and CAL (dependent variable) (<jats:italic>P<\/jats:italic> = 0.009\/<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.05 and <jats:italic>P<\/jats:italic> = 0.005\/<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.07, respectively) had significant association with hsCRP. Furthermore, hsCRP, when considered as outcome, also exhibited association with CAL and WC (<jats:italic>P<\/jats:italic> = 0.002\/<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.07 and <jats:italic>P<\/jats:italic> = 0.04\/<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.106). Logistic regression analysis demonstrated that the PCOS\u2010N group had 2.88 times increased likelihood of having moderate periodontitis (adjusted odds ratio 2.88, 95% confidence interval 1.18 to 6.98).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Women with newly diagnosed PCOS may have increased prevalence and likelihood for periodontitis, with higher measures of periodontal inflammation and breakdown than those on medical treatment for PCOS and systemically healthy females. Furthermore, periodontal breakdown might depend on systemic inflammation and vice versa.<\/jats:p>","DOI":"10.1902\/jop.2014.130756","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T08:50:54Z","timestamp":1393923054000},"page":"1380-1389","source":"Crossref","is-referenced-by-count":48,"title":["Periodontal Status and High\u2010Sensitivity C\u2010Reactive Protein Levels in Polycystic Ovary Syndrome With and Without Medical Treatment"],"prefix":"10.1002","volume":"85","author":[{"given":"Surya","family":"Porwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajinder K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita Rani","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish C.","family":"Narula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513598709023610"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02725-4"},{"key":"e_1_2_7_4_1","first-page":"3078","article-title":"Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study","volume":"83","author":"Konchenhauer ES","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03111-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.3.231"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13409-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb01744.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(96)80085-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200306000-00011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509283331307"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-1-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1993.tb01016.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.6.7580"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070605"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0402"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00689.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.51"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.257"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1366.032"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790010701"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300213"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01179.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1528"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01017.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2011.06.002"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.07.1052"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110588"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120483"},{"key":"e_1_2_7_31_1","first-page":"1","volume-title":"Ethical principles for medical research involving human subjects","author":"WHO","year":"2008"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_7_33_1","first-page":"5","volume-title":"Waist circumference and waist\u2010hip ratio: Report of a WHO expert consultation","author":"WHO","year":"2008"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110664"},{"key":"e_1_2_7_38_1","unstructured":"SN Daftary"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)30642-6"},{"key":"e_1_2_7_40_1","unstructured":"GG Mukherjee"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1058085"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2725"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00052-2"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509337479"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100321"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.7.1729"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0461"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040769"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021688"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031096"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080561"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2014.130756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:59:58Z","timestamp":1760871598000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2014.130756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1902\/jop.2014.130756"],"URL":"https:\/\/doi.org\/10.1902\/jop.2014.130756","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}