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The mandibles and tibias of these mice were retrieved for microcomputed tomography (micro\u2010CT), histomorphometric analysis, and isolation of ABCs 16 weeks after T\u2010cell transfer. The in vitro osteogenic and adipogenic potentials of the ABCs were evaluated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Histologic and micro\u2010CT analysis revealed that the transfer of CD4<jats:sup>+<\/jats:sup>CD45RB<jats:sup>High<\/jats:sup> T\u2010cell subset was sufficient for alveolar bone resorption and affected the osteogenic\/adipogenic potential of ABCs. Furthermore, it was found that CD4<jats:sup>+<\/jats:sup>CD45RB<jats:sup>High<\/jats:sup> T\u2010cell\u2013transferred animals have decreased systemic osteogenic potential, as evidenced using the in vivo ectopic hPDLSC transplantation model.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> CD4<jats:sup>+<\/jats:sup>CD45RB<jats:sup>High<\/jats:sup> T\u2010cell transfer induced both alveolar bone resorption and reduced systemic osteogenic potential, with a concomitant downregulation of the osteogenic potential of ABCs.<\/jats:p>","DOI":"10.1902\/jop.2014.140077","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T01:27:04Z","timestamp":1396229224000},"source":"Crossref","is-referenced-by-count":2,"title":["Alveolar Bone Resorption Induced by CD4<sup>+<\/sup>CD45RB High\u2010Density T\u2010Cell Transfer in Immunocompromised Mice"],"prefix":"10.1002","volume":"85","author":[{"given":"Jung\u2010Chul","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Kyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Im\u2010Hee","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunyoung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"177","article-title":"The immune response of germ\u2010free piglets after peroral monocontamination with living Escherichia coli strain 086. 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