{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:11:07Z","timestamp":1783015867980,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The comparative treatment response of children and young adults with localized aggressive periodontitis treatment (LAgP) affecting primary and permanent dentition is unknown. The objective of this study is to evaluate the influence of non\u2010surgical periodontal therapy with adjunctive systemic antibiotics on the clinical outcome of children and young adults with primary versus permanent dentition affected by LAgP.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A cohort of 97 African American participants aged 5 to 21 years (30 males and 67 females; 22 primary and 75 permanent dentitions affected) diagnosed with LAgP were included. Patients presented with no significant medical history. All patients underwent periodontal therapy, which consisted of full\u2010mouth mechanical debridement at baseline and the 3\u2010, 6\u2010, and 12\u2010month appointments. Additionally, all patients were prescribed a 1\u2010week regimen of systemic antibiotics at the initial appointment. Clinical parameters were analyzed, including probing depth, clinical attachment level (CAL), bleeding on probing, and percentage of visible plaque.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Overall, periodontal therapy was found to be effective in improving the clinical outcomes of both primary and permanent dentitions. Although baseline CALs were similar between the groups, the reduction in mean CAL at 3, 6, and 12 months and reduction in percentage plaque at 3 months were significantly greater in primary dentition compared with permanent dentition.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Non\u2010surgical therapy with systemic antibiotics is effective for LAgP in both primary and permanent dentitions. A greater reduction in CAL in LAgP of primary dentition may suggest that younger children may carry a greater propensity for positive treatment outcomes and healing potential compared with children\/young adults with permanent dentition.<\/jats:p>","DOI":"10.1902\/jop.2014.140171","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T09:30:32Z","timestamp":1409823032000},"page":"1722-1729","source":"Crossref","is-referenced-by-count":25,"title":["Localized Aggressive Periodontitis Treatment Response in Primary and Permanent Dentitions"],"prefix":"10.1002","volume":"85","author":[{"given":"Sherin N.","family":"Merchant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vovk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Kalash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Hovencamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikramuddin","family":"Aukhil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Zapert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Varnado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana M.","family":"Shaddox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290504.x"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Consensus report: Aggressive periodontitis","volume":"4","author":"Lang N","year":"1999","journal-title":"Anal Periodontol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290108.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.5.330"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"MasamattiSS KumarA VirdiMS. 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