{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:46:53Z","timestamp":1790012813990,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Periodontitis is an inflammatory chronic disease that has been implicated as a risk factor for cardiovascular disease (CVD). Endothelium has a central role in CVD pathogenesis, and chronic inflammation can make it dysfunctional, contributing to CVD emergence. Thus, the aim of this study is to investigate the existence of an association between severe chronic periodontitis (CP) and nailfold microvascular, gingival microvascular, and endothelial functions.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010three patients were included, 13 with severe periodontitis (median age, 46 years; interquartile range, 9.5 years) and 10 healthy control patients (median age, 35.5 years; interquartile range, 12.5 years). Clinical and laboratorial variables were gathered, and patients were examined by the following: 1) nailfold videocapillaroscopy to assess functional capillary density (FCD), capillary diameters, red blood cell velocity at rest (RBCV) and after 1\u2010minute arterial occlusion (RBCV<jats:sub>max<\/jats:sub>), and time taken to reach RBCV<jats:sub>max<\/jats:sub> (TRBCV<jats:sub>max<\/jats:sub>); 2) side\u2010stream dark\u2010field imaging to determine gingival capillary density (GCD); and 3) venous occlusion plethysmography to assess endothelium\u2010dependent (% Hyper) and endothelium\u2010independent vasodilatation (% Nitro).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Patients with CP have smaller values for FCD, RBCV, RBCV<jats:sub>max<\/jats:sub>, and % Hyper and higher values for TRBCV<jats:sub>max<\/jats:sub> and GCD compared with controls (<jats:italic>P<\/jats:italic> &lt;0.05). There were significant correlations between periodontal parameters with FCD, RBCV, RBCV<jats:sub>max<\/jats:sub>, TRBCV<jats:sub>max<\/jats:sub>, GCD, and % Hyper. There was also a negative correlation between FCD and GCD (<jats:italic>r<\/jats:italic> = \u22120.7; <jats:italic>P<\/jats:italic> &lt;0.01). Associations between periodontitis and FCD, RBCV<jats:sub>max<\/jats:sub>, TRBCV<jats:sub>max<\/jats:sub>, GCD, and % Hyper remained significant after adjustments for age and systolic blood pressure.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Severe CP was directly associated with endothelial and microvascular dysfunctions.<\/jats:p>","DOI":"10.1902\/jop.2014.140189","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T08:43:16Z","timestamp":1412239396000},"page":"1648-1657","source":"Crossref","is-referenced-by-count":37,"title":["Severe Chronic Periodontitis Is Associated With Endothelial and Microvascular Dysfunctions: A Pilot Study"],"prefix":"10.1002","volume":"85","author":[{"given":"Ronaldo","family":"Lira\u2010Junior","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Marcelo","family":"Figueredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliete","family":"Bouskela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Guimar\u00e3es","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-80"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.711507"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12062"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.07.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000078603.90302.4A"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.10.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063186"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.03.037"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.101535"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12110"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.091158"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.089680"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","unstructured":"WiernspergerNF BouskelaE. Microcirculation in insulin resistance and diabetes: More than just a complication.Diabetes Metab2003;29(4 Pt 2):6S77\u20106S87.","DOI":"10.1016\/S1262-3636(03)72791-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.05.019"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711263172202"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2442"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2003.01179.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.763730"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2009.00015.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2004.00588.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmte.1997.42.6.168"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.38.2.238"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1990.tb00825.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2011.01.002"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12066"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00118.2003"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510375830"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(87)90077-X"},{"key":"e_1_2_7_33_1","first-page":"345","article-title":"Reactive hyperaemia in skin of the human foot measured by laser Doppler flowmetry: Effects of duration of ischaemia and local heating","volume":"9","author":"Walmsley D","year":"1990","journal-title":"Int J Microcirc Clin Exp"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02082.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2009.08.003"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2012.10.009"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1698963"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100079"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833e0fe1"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01800.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.4.998"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322008000500008"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00450-3"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.08.004"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027008537.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0072"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12162"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1085"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328333d1fc"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.1.50"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.291004.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2014.140189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:33:03Z","timestamp":1760884383000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2014.140189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1902\/jop.2014.140189"],"URL":"https:\/\/doi.org\/10.1902\/jop.2014.140189","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}