{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:30:07Z","timestamp":1777120207687,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Several studies have investigated the association between interleukin (IL)\u20104 gene \u2212590 C\/T, \u221233 C\/T, or 70\u2013base pair (70\u2010bp) polymorphisms and periodontitis susceptibility but with conflicting results. Hence, a meta\u2010analysis was conducted to explore whether these polymorphisms are associated with periodontitis susceptibility.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A comprehensive literature search was conducted of PubMed, Embase, Scopus, ScienceDirect, and Web of Science up to April 5, 2014. After the eligible studies were identified, data were extracted and quality\u2010assessed before performing the meta\u2010analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The meta\u2010analysis included 23 eligible case\u2010control studies from 11 articles involving 12 studies of the \u2212590 C\/T polymorphism (1,220 cases and 2,039 controls), five of the \u221233 C\/T polymorphism (715 cases and 967 controls), and four of the 70\u2010bp polymorphism (426 cases and 506 controls). The meta\u2010analysis showed that none of these IL\u20104 gene polymorphisms were significantly associated with periodontitis susceptibility in all study participants. However, subgroup analysis showed that the IL\u20104 \u2212590 T allele (odds ratio [OR] = 1.2, 95% confidence interval [CI] = 1.02 to 1.42, <jats:italic>P<\/jats:italic> = 0.03) and TT genotype (OR = 1.68, 95% CI = 1.05 to 2.67, <jats:italic>P<\/jats:italic> = 0.03) were associated with periodontitis in whites.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Based on current evidence, the IL\u20104 \u221233 C\/T and 70\u2010bp polymorphisms were not associated with an increased risk of periodontitis. However, the IL\u20104 \u2212590 T allele and TT genotype were associated with increased risk of periodontitis in whites.<\/jats:p>","DOI":"10.1902\/jop.2014.140317","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T09:45:40Z","timestamp":1405503940000},"source":"Crossref","is-referenced-by-count":28,"title":["Association Between Interleukin\u20104 Gene \u2212590 C\/T, \u221233 C\/T, and 70\u2010Base\u2010Pair Polymorphisms and Periodontitis Susceptibility: A 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