{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:04:35Z","timestamp":1792512275996,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this case\u2010control study with an intervention arm is to determine the effect of initial periodontal treatment on oxidative stress biomarkers in smokers and non\u2010smokers with chronic periodontitis (CP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study included 47 patients with CP (24 smokers [S+P+] and 23 non\u2010smokers [S\u2212P+]) and 46 periodontally healthy individuals (23 smokers [S+P\u2212] and 23 non\u2010smokers [S\u2212P\u2212]) for a total of 93 participants. Gingival crevicular fluid (GCF), serum, and saliva samples were obtained and clinical periodontal measurements were recorded at baseline and at the first and third months after periodontal therapy. 8\u2010hydroxydeoxyguanosine (OHdG) and 4\u2010hydroxynonenal (HNE) and enzyme activity of glutathione peroxidase (GSH\u2010Px) were analyzed with enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The level of 8\u2010OHdD in GCF was found to be significantly higher in both periodontitis groups compared with both periodontally healthy groups. 8\u2010OHdG and GSH\u2010Px in saliva in both periodontitis groups were significantly increased compared with the S\u2212P\u2212 group. In the S+P+ group, 4\u2010HNE in GCF was found to be significantly higher than in periodontally healthy participants. After initial periodontal treatment, the levels of 8\u2010OHdG in GCF and saliva were significantly decreased in both periodontitis groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Initial periodontal therapy may be helpful for diminishing oxidative stress in periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2014.140338","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T11:35:43Z","timestamp":1413545743000},"page":"273-282","source":"Crossref","is-referenced-by-count":67,"title":["Effect of Initial Periodontal Therapy on Oxidative Stress Markers in Gingival Crevicular Fluid, Saliva, and Serum in Smokers and Non\u2010Smokers With Chronic Periodontitis"],"prefix":"10.1002","volume":"86","author":[{"given":"Meltem Karsiyaka","family":"Hendek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru 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