{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:47:29Z","timestamp":1791218849920,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The purpose of this study is to evaluate whether \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP) could be a promising modality to help augment alveolar bone in periodontal tissue regeneration by bone marrow mesenchymal stem cells (BMMSCs).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Expanded BMMSCs and atelocollagen (Col) were mixed together (MSC\/Col). A combination of \u03b2\u2010TCP with MSC\/Col was also prepared (MSC\/Col\/TCP). MSC\/Col\/TCP or MSC\/Col was transplanted into experimental periodontal Class III furcation defects that had been exposed to inflammation in beagle dogs. Periodontal tissue regeneration was evaluated by histologic and morphometric analyses at 4 and 8 weeks after transplantation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    MSC\/Col and MSC\/Col\/TCP enhanced periodontal tissue regeneration compared to Col and TCP\/Col according to hematoxylin and eosin staining. The percentage of new cementum length in the MSC\/Col\/TCP group was not significantly different from that in the MSC\/Col group at 4 and 8 weeks. On the other hand, the percentage of new bone area in the MSC\/Col\/TCP group was much higher than that in the MSC\/TCP group at 4 weeks. However, at 8 weeks, no significant difference in new bone area was found between the two groups. In the MSC\/Col\/TCP group, \u03b2\u2010TCP was surrounded by newly formed bone. Multinucleated cells, which were positive for osteopontin and tartrate\u2010resistant acid phosphatase, were present in the interconnected macropores of \u03b2\u2010TCP.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    These findings suggest that \u03b2\u2010TCP is applicable as a scaffold for BMMSCs transplantation and helps augment alveolar bone without impairing regeneration of cementum.\n                  <\/jats:p>","DOI":"10.1902\/jop.2014.140384","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T09:13:03Z","timestamp":1418375583000},"page":"456-464","source":"Crossref","is-referenced-by-count":37,"title":["Introduction of a Mixture of \u03b2\u2010Tricalcium Phosphate Into a Complex of Bone Marrow Mesenchymal Stem Cells and Type I Collagen Can Augment the Volume of Alveolar Bone Without Impairing Cementum Regeneration"],"prefix":"10.1002","volume":"86","author":[{"given":"Takayosi","family":"Nagahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Yoshimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Shiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503845200"},{"key":"e_1_2_7_3_1","first-page":"91","article-title":"Human bone marrow mesenchymal stem cells differentiate into neuron\u2010like cells in vitro","volume":"9","author":"Guo ZK","year":"2001","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(199702)64:2<295::AID-JCB12>3.0.CO;2-I"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9645"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1998.4.415"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/S1110724304306017"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101442"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01798.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050341"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.9.1281"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070577"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00328-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090386"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(20000305)49:3<328::AID-JBM5>3.0.CO;2-Q"},{"issue":"181","key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00003086-198312000-00040","article-title":"Osteogenesis after bone and bone marrow transplantation. 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