{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:07:37Z","timestamp":1780081657872,"version":"3.54.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23792103"],"award-info":[{"award-number":["23792103"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25462854"],"award-info":[{"award-number":["25462854"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    F\u2010spondin, known to be a secreted neuronal glycoprotein, is highly expressed on the tooth root surface. The authors previously reported that F\u2010spondin is one of the specific markers of cementoblasts in periodontal tissue. In chronic periodontitis, significant cemental resorption rarely occurs on the root side, although alveolar bone resorption by osteoclasts is one of the major pathologic changes. Thus, it was hypothesized that secretory F\u2010spondin from cementoblasts might be involved in differentiation of clastic cells on the root surface. The authors studied effects of secretory F\u2010spondin from F\u2010spondin\u2013expressing cells and its pathway on receptor activator of nuclear factor\u2010\u03baB ligand (RANKL)\u2010mediated differentiation of clastic cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Osteoclast precursors were used in this study. With a chamber assay, the authors examined effects of secretory molecules from F\u2010spondin\u2013expressing cells of transgenic mice on RANKL\u2010induced clastic cell differentiation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Secretory molecules from F\u2010spondin\u2013overexpressing cells significantly inhibited the RANKL\u2010mediated tartrate\u2010resistant acid phosphatase (TRAP)\u2010positive cells from primary progenitor cells with the chamber system. F\u2010spondin suppressed RANKL\u2010mediated nuclear factor of activated T\u2010cells, cytoplasmic 1 (NFATc1); TRAP; cathepsin K; and dendritic cell\u2013specific transmembrane protein (DC\u2010STAMP) expression in the cells. The suppressive effect of F\u2010spondin on RANKL\u2010induced differentiation of clastic cells was partially blocked by knockdown of low\u2010density lipoprotein receptor\u2013related protein 8 (LRP8).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These findings indicate that secretory factors from F\u2010spondin\u2013expressing cells, including F\u2010spondin, downregulate differentiation of clastic precursors. Moreover, F\u2010spondin inhibits RANKL\u2010mediated differentiation of clastic cells partially via LRP8. It is suggested that secretory F\u2010spondin may act protectively from cemental resorption partially via LRP8 in periodontal tissue.\n                  <\/jats:p>","DOI":"10.1902\/jop.2014.140419","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T11:48:57Z","timestamp":1412855337000},"page":"465-472","source":"Crossref","is-referenced-by-count":4,"title":["F\u2010Spondin Inhibits Differentiation of Clastic Precursors via Lipoprotein Receptor\u2013Related Protein 8 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