{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:56:06Z","timestamp":1787759766435,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti\u2010citrullinated protein antibody (ACPA)\u2010positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations, including multiple antigen\u2013specific ACPA.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This multicenter case\u2010control study includes 617 patients diagnosed with RA (n = 287) or OA (n = 330). Panoramic radiographs were taken; patients were categorized into low, moderate, or high tertiles based on mean percentage ABL. Serum ACPA was measured using second\u2010generation anticyclic citrullinated peptide enzyme\u2010linked immunosorbent assay and a multiplex platform to assess distinct antigen\u2010specific ACPA. A generalized linear mixed model for binary data was used to compare stratified ABL in RA versus OA patients. Associations of moderate and high ABL (versus low) with RA disease activity and severity measures were examined using multivariate regression. Antigen\u2010specific ACPA responses were compared among ABL tertiles using significance analysis of microarrays.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> ACPA\u2010positive patients with RA had a significantly higher mean percentage of sites with ABL &gt;20% compared with patients with OA (<jats:italic>P<\/jats:italic> = 0.03). After multivariate adjustment, greater ABL was significantly associated with higher serum ACPA concentration (<jats:italic>P<\/jats:italic> = 0.004), 28\u2010joint Disease Activity Score (<jats:italic>P<\/jats:italic> = 0.023), health assessment questionnaire disability (<jats:italic>P<\/jats:italic> = 0.05), tender joint count (<jats:italic>P<\/jats:italic> = 0.02) and joint space narrowing scores (<jats:italic>P<\/jats:italic> = 0.05) among patients with RA. ACPAs targeting citrullinated vimentin and histone were significantly higher in moderate and high ABL groups versus low, regardless of smoking status (<jats:italic>q<\/jats:italic> &lt;0.1%).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Greater ABL was associated with higher ACPA, consistent with findings at articular sites. ACPA targeting could provide novel insight into important linkages between RA and periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2014.140425","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T11:48:57Z","timestamp":1412855337000},"page":"222-231","source":"Crossref","is-referenced-by-count":37,"title":["Alveolar Bone Loss Is Associated With Circulating Anti\u2010Citrullinated Protein Antibody (ACPA) in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"86","author":[{"given":"Shawneen M.","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey 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