{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:20:59Z","timestamp":1783419659593,"version":"3.54.6"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Gestational diabetes mellitus (GDM) is defined as varying glucose intolerance, with first onset or recognition in pregnancy. This study evaluates clinical and biochemical parameters in a possible association between GDM and gingivitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A total of 167 pregnant females was included in the study. There were 101 females with GDM and 66 females without GDM. Subgroups were created according to the presence or absence of gingival inflammation. Plaque index, bleeding on probing, and probing depth were recorded at four sites per tooth. Serum, saliva, and gingival crevicular fluid (GCF) levels of interleukin (IL)\u20106, IL\u20108, soluble receptor activator of nuclear factor\u2010kappa B ligand (sRANKL), osteoprotegerin (OPG), B\u2010cell activating factor (BAFF), and a proliferation\u2010inducing ligand (APRIL) were determined by enzyme\u2010linked immunosorbent assay. Data were analyzed by Kruskal\u2010Wallis and Mann\u2010Whitney\n                    <jats:italic>U<\/jats:italic>\n                    tests and Spearman correlation analysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Age and anthropometric indices were higher in the GDM than non\u2010GDM group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001). Clinical periodontal recordings, serum BAFF, IL\u20108, and saliva sRANKL levels were higher in the GDM group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Saliva IL\u20106 level was higher in the GDM with gingivitis group than non\u2010GDM with gingivitis group (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.044). Serum and GCF BAFF (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001), serum, saliva, and GCF APRIL (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.032, respectively), GCF OPG (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.036), and serum and saliva sRANKL (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001) were higher in the GDM with gingivitis group than GDM without gingivitis group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The inflammatory response seems to be more pronounced in females with GDM. The observed increase in both local and systemic levels of inflammatory cytokines may suggest an interaction between gingivitis and GDM.\n                  <\/jats:p>","DOI":"10.1902\/jop.2014.140444","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T07:17:07Z","timestamp":1418282227000},"page":"387-397","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of Biochemical Parameters and Local and Systemic Levels of Osteoactive and B\u2010Cell Stimulatory Factors in Gestational Diabetes in the Presence or Absence of Gingivitis"],"prefix":"10.1002","volume":"86","author":[{"given":"P\u0131nar","family":"G\u00fcm\u00fc\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcn","family":"\u00d6z\u00e7aka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Ceyhan\u2010\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliye","family":"Akcali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Lappin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Buduneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00199.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01630.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260309.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2009.00830.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.04.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00945.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04007.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038429"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.12.018"},{"key":"e_1_2_8_12_1","first-page":"135","article-title":"Immunohistochemical evaluation of inflammatory mediators in failing implants","volume":"26","author":"Konttinen YT","year":"2006","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01480.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.3.0367"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/16852"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-s201"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.11.001"},{"key":"e_1_2_8_18_1","first-page":"525","article-title":"Clinical management guidelines for obstetrician\u2010gynecologists. 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