{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:20:12Z","timestamp":1772706012263,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This review assesses the associations of interleukin\u20108 gene (<jats:italic>IL\u20108<\/jats:italic>) \u2212251A\/T (rs4073) and \u2212845T\/C (rs2227532) polymorphisms with susceptibility to periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Several electronic databases were searched for eligible articles. Twelve studies involving 2,233 cases and 2,655 controls were retrieved and analyzed. Odds ratios (ORs) along with 95% confidence intervals (CIs) were calculated to assess the strength of relationship between the <jats:italic>IL\u20108<\/jats:italic> polymorphisms and periodontitis risk.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> No significant association was found for <jats:italic>IL\u20108<\/jats:italic> \u2212251A\/T polymorphism with periodontitis in the overall analysis and stratification by periodontitis type and smoking status. Subgroup analysis by ethnicity revealed that \u2212251A\/T T allele and TT genotype were associated with decreased risk of periodontitis in a Brazilian mixed population (T allele versus A allele: OR 0.80, 95% CI 0.68 to 0.94, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub> = 0.30; TT versus AA: OR 0.65, 95% CI 0.46 to 0.93, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub> = 0.39; TT versus AA\/AT: OR 0.58, 95% CI 0.35 to 0.98, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub> = 0.01). In addition, \u2212251A\/T T allele was associated with increased periodontitis risk in Asians. Pooled estimates showed that the \u2212845T\/C polymorphism was associated with periodontitis susceptibility in overall analysis and the chronic periodontitis subgroup. In addition, marginal associations were observed between \u2212845T\/C polymorphism and periodontitis in a Brazilian mixed population. Moreover, this association was also confirmed to be significant in Brazilian non\u2010smokers.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This meta\u2010analysis indicated that both <jats:italic>IL\u20108<\/jats:italic> \u2212251A\/T and \u2212845T\/C polymorphisms may be involved in the development of periodontitis in a Brazilian mixed population, whereas the \u2212251A\/T allele T appeared to be a risk factor for periodontitis in Asians.<\/jats:p>","DOI":"10.1902\/jop.2014.140450","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T11:48:57Z","timestamp":1412855337000},"page":"292-300","source":"Crossref","is-referenced-by-count":26,"title":["Quantitative Assessment of the Associations Between Interleukin\u20108 Polymorphisms and Periodontitis Susceptibility"],"prefix":"10.1002","volume":"86","author":[{"given":"Xing","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangjun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.32"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00413.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290107.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003421.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.7.711"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1989.tb00626.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12279"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.01.016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110655"},{"key":"e_1_2_7_11_1","first-page":"456","article-title":"The role of interleukin\u20108 in inflammation and mechanisms of regulation","volume":"64","author":"Bickel M","year":"1993","journal-title":"J Periodontol"},{"key":"e_1_2_7_12_1","first-page":"299","article-title":"Tissue destruction in periodontitis: Bacteria or cytokines fault?","volume":"36","author":"Bascones A","year":"2005","journal-title":"Quintessence Int"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.12.1023"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.033050"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0326"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2008.0816"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100513"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083286"},{"key":"e_1_2_7_19_1","first-page":"312","article-title":"Association of IL\u20108 (\u2010251 A\/T) gene polymorphism with clinical parameters and chronic periodontitis","volume":"10","author":"Khosropanah H","year":"2013","journal-title":"J Dent (Tehran)"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/342351"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.06.239"},{"key":"e_1_2_7_22_1","first-page":"427","article-title":"Evaluation of IL\u20108 gene polymorphisms in patients with periodontitis in Hamedan, Iran","volume":"9","author":"Houshmand B","year":"2012","journal-title":"Dent Res J (Isfahan)"},{"key":"e_1_2_7_23_1","first-page":"471","article-title":"Interleukin\u20108 \u2010251 gene polymorphism in Chinese patients with aggressive periodontitis (in Chinese)","volume":"19","author":"Li J","year":"2011","journal-title":"J Dent Prev Treat"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.05.014"},{"key":"e_1_2_7_25_1","unstructured":"ZhangZP. 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