{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:08:57Z","timestamp":1791644937995,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Different gingival crevicular fluid (GCF) matrix metalloproteinase (MMP)\u20108 response patterns were studied among non\u2010smoking and smoking patients with chronic periodontitis (CP) and generalized aggressive periodontitis (GAgP) to test the utility of GCF MMP\u20108 levels predicting the site\u2010level treatment outcome.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Data from four independent longitudinal studies were combined. Altogether, the studies included 158 periodontal sites from 67 patients with CP and 32 patients with GAgP, and GCF samples were collected at baseline, after the treatment, and during the 6\u2010month maintenance period. All GCF samples were analyzed by immunofluorometric assay for MMP\u20108. Different site\u2010level MMP\u20108 response patterns were explored by the cluster analysis. Most optimal MMP\u20108 cutoff levels were searched with receiver operating characteristic analyses, and the predictive utility of defined levels was tested.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Distinct types of MMP\u20108 response patterns were found in both smokers and non\u2010smokers. MMP\u20108 levels exceeding the optimal cutoff levels separately defined for smokers and non\u2010smokers indicated increased risk for compromised treatment outcome at baseline and during the maintenance period. Seventy\u2010one percent of non\u2010smokers (positive likelihood ratio of 4.22) and 88% of smokers (positive likelihood ratio of 5.00) with positive test results at both baseline and the maintenance period had compromised treatment outcome. The double\u2010positive result indicated 46% and 39% point risk increase for the compromised outcome, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> GCF MMP\u20108 analysis with defined cutoff levels could be used to predict the site\u2010level treatment outcome and for longitudinal monitoring of the disease status during the maintenance period.<\/jats:p>","DOI":"10.1902\/jop.2015.140421","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T10:20:32Z","timestamp":1425550832000},"page":"777-787","source":"Crossref","is-referenced-by-count":48,"title":["The Utility of Gingival Crevicular Fluid Matrix Metalloproteinase\u20108 Response Patterns in Prediction of Site\u2010Level Clinical Treatment Outcome"],"prefix":"10.1002","volume":"86","author":[{"given":"Jussi M.","family":"Leppilahti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko A.","family":"Kallio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"Tervahartiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclnur","family":"Emingil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buket","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"M\u00e4ntyl\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00107.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080363"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.7.363"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1994.tb01811.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.106"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510375281"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01274.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00799.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2013.0096"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2004.01038.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07679.x"},{"key":"e_1_2_8_14_1","article-title":"Analysis of matrix metalloproteinases in gingival crevicular fluid (GCF), mouthrinse and saliva for monitoring periodontal diseases","author":"Sorsa T","year":"2014","journal-title":"Periodontol 2000"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.09.68"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600800103"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01603.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.10.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01753.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01716.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130156"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12223"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511399908"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110060"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12194"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607254104"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00677.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00897.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12234"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/621484"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01488.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.1.106"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110519"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.50.31504"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02108.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7458.168"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01305.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00873-08"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01310.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090374"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2015.140421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:14:40Z","timestamp":1760868880000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2015.140421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1902\/jop.2015.140421"],"URL":"https:\/\/doi.org\/10.1902\/jop.2015.140421","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}