{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:22:44Z","timestamp":1785349364270,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008269","name":"Michigan Institute for Clinical and Health Research","doi-asserted-by":"publisher","award":["UL1RR024986"],"award-info":[{"award-number":["UL1RR024986"]}],"id":[{"id":"10.13039\/100008269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["1K23DEO21779"],"award-info":[{"award-number":["1K23DEO21779"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["5K22 DE20197"],"award-info":[{"award-number":["5K22 DE20197"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Aromatase inhibitor (AI) use results in low estrogen levels, which in turn affect bone mineral density (BMD). Periodontitis, alveolar bone loss, and tooth loss are associated with low BMD. The goal of this study is to assess the prevalence of periodontitis and perceived oral health and evaluate salivary biomarkers in postmenopausal women who are survivors of early\u2010stage (I to IIIA) breast cancer (BCa) and receive adjuvant AI therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Participants included 58 postmenopausal women: 29 with BCa on AIs and 29 controls without BCa diagnoses. Baseline periodontal status was assessed with: 1) periodontal probing depth (PD); 2) bleeding on probing (BOP); and 3) attachment loss (AL). Demographic and dental utilization information was gathered by questionnaire. Linear regression modeling was used to analyze the outcomes.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> No differences were found in mean PD or number of teeth. The AI group had significantly more sites with BOP (27.8 versus 16.7; <jats:italic>P<\/jats:italic> = 0.02), higher worst\u2010site AL (5.2 versus 4.0 mm; <jats:italic>P<\/jats:italic> &lt;0.01), and more sites with dental calculus (18.2 versus 6.4; <jats:italic>P<\/jats:italic> &lt;0.001) than controls. Linear regression adjusted for income, tobacco use, dental insurance, and previous radiation and chemotherapy exposure demonstrated that AI use increased AL by &gt;2 mm (95% confidence interval, 0.46 to 3.92). Median salivary osteocalcin and tumor necrosis factor\u2010\u03b1 levels were significantly higher in the AI group than the control group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This first investigation of the periodontal status of women initiating adjuvant AI therapy identifies this population as having an increased risk for periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2015.140546","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T05:49:26Z","timestamp":1423720166000},"page":"906-916","source":"Crossref","is-referenced-by-count":26,"title":["Periodontal Health in Women With Early\u2010Stage Postmenopausal Breast Cancer Newly on Aromatase Inhibitors: A Pilot Study"],"prefix":"10.1002","volume":"86","author":[{"given":"L. 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