{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:12:07Z","timestamp":1790255527958,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of this study is to determine the serum levels of malondialdehyde (MDA), as a lipid peroxidation marker, and 8\u2010hydroxydeoxyguanosine (8\u2010OHdG), as an oxidative DNA damage marker, in patients with chronic periodontitis (CP) and hyperlipidemia.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 74 individuals were divided into four age\u2010 and sex\u2010matched groups: 18 patients with hyperlipidemia and CP (HLp), 18 periodontally healthy patients with hyperlipidemia (HLh), 19 systemically healthy individuals with CP (Cp), and 19 systemically and periodontally healthy controls (Ch). Clinical periodontal parameters were measured, and serum lipids, MDA, and 8\u2010OHdG levels were assessed in blood samples.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> 8\u2010OHdG, MDA, probing depth, clinical attachment level, and percentage of sites bleeding on probing (BOP) were significantly higher in the HLp group than the Cp group. In the hyperlipidemic group, BOP was significantly correlated with total cholesterol, the ratio of total cholesterol to high\u2010density lipoprotein cholesterol, and 8\u2010OHdG levels. A significant correlation between 8\u2010OHdG and MDA was also observed in the hyperlipidemia group.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In this study, serum MDA and 8\u2010OHdG were found to be highest in the HLp group. The increased levels of MDA and 8\u2010OHdG in HLp patients may be a result of a harmful oxidative status in association with hyperlipidemia and periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2015.140561","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T05:04:43Z","timestamp":1421989483000},"page":"682-688","source":"Crossref","is-referenced-by-count":58,"title":["Evaluation of Lipid Peroxidation and Oxidative DNA Damage in Patients With Periodontitis and Hyperlipidemia"],"prefix":"10.1002","volume":"86","author":[{"given":"\u00d6zlem","family":"Fento\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Ye\u015fim","family":"K\u0131rz\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Memduha T\u00f6z\u00fcm","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Kumbul Do\u011fu\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin","family":"Kula\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"\u00d6nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"G\u00fcnhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(90)90119-U"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/908539"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090270"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.10.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-009-0026-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697415"},{"key":"e_1_2_8_9_1","first-page":"875","article-title":"Morphological examinations of hard tissues of periodontium and evaluation of selected processes of lipid peroxidation in blood serum of rats in the course of experimental periodontitis","volume":"6","author":"Sobaniec H","year":"2000","journal-title":"Med Sci Monit"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2001.70109.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.05.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","unstructured":"ChiouCC ChangPY ChanEC WuTL TsaoKC WuJT. Urinary 8\u2010hydroxydeoxyguanosine and its analogs as DNA marker of oxidative stress: Development of an ELISA and measurement in both bladder and prostate cancers.Clin Chim Acta2003;34:87\u201094.","DOI":"10.1016\/S0009-8981(03)00191-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2003.09.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2013.04.064"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.11.013"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.5.551"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00215.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/215430"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120195"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.47.53"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050459"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00771.x"},{"key":"e_1_2_8_23_1","first-page":"47","article-title":"Periodontal disease: Links with serum lipid\/triglyceride levels? Review and new data","volume":"5","author":"Cutler CW","year":"2003","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027008537.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080104"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80933-T"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01678.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1375"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.05.041"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-007-0047-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(00)00426-5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007794531046"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-I"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100417"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01644.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028009865.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(97)00035-5"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00818-3"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.01.008"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01212.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.01.004"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02630732"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2008.010"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2015.140561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:38:27Z","timestamp":1760884707000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2015.140561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1902\/jop.2015.140561"],"URL":"https:\/\/doi.org\/10.1902\/jop.2015.140561","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}