{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:02:53Z","timestamp":1793314973294,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study evaluates the effects on clinical and biochemical parameters of <jats:italic>Lactobacillus reuteri<\/jats:italic>\u2013containing probiotic supplementation adjunctive to initial periodontal therapy in patients with chronic periodontitis (CP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty patients with CP were included and divided into two groups. Every patient had, in each quadrant, \u22652 teeth each with approximal sites with a probing depth (PD) of 5 to 7 mm and gingival index (GI) of \u22652. The test group received scaling and root planing (SRP) and probiotic\u2010containing lozenges. The control group received SRP and placebo lozenges. Plaque index (PI), GI, bleeding on probing (BOP), PD, and attachment gain were measured. Gingival crevicular fluid (GCF) was sampled for the analysis of matrix metalloproteinase (MMP)\u20108 and tissue inhibitor of metalloproteinase (TIMP)\u20101 by enzyme\u2010linked immunosorbent assay. All evaluations were performed at baseline and on days 21, 90, 180, and 360.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Differences in intergroup comparisons of PI, GI, BOP, and PD were found to be significant (<jats:italic>P<\/jats:italic> &lt;0.05) in favor of the test group at all time points. Decreased GCF MMP\u20108 levels and increased TIMP\u20101 levels were found to be significant up to day 180 (<jats:italic>P<\/jats:italic> &lt;0.05). Mean values of attachment gain were significantly higher in the test group compared with the control group on days 90, 180, and 360.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Lozenges containing <jats:italic>L. reuteri<\/jats:italic> may be a useful supplement in moderately deep pockets of patients with CP. Low MMP\u20108 and high TIMP\u20101 levels may indicate the role of the lozenges in reduction of inflammation\u2010associated markers up to day 180.<\/jats:p>","DOI":"10.1902\/jop.2015.140612","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T10:20:32Z","timestamp":1425550832000},"page":"746-754","source":"Crossref","is-referenced-by-count":176,"title":["Clinical and Biochemical Evaluation of Lozenges Containing <i>Lactobacillus reuteri<\/i> as an Adjunct to Non\u2010Surgical Periodontal Therapy in Chronic Periodontitis"],"prefix":"10.1002","volume":"86","author":[{"given":"Gizem","family":"\u0130nce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hare","family":"G\u00fcrsoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eebnem Dirikan","family":"\u0130p\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokser","family":"Cakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Emekli\u2010Alturfan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sel\u00e7uk","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Food and Agriculture Organization\/World Health Organization. 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