{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:34:38Z","timestamp":1771936478909,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The benefit of full\u2010mouth disinfection (FDIS) over traditional scaling and root planing (SRP), with or without adjunctive metronidazole, when treating chronic destructive periodontitis remains equivocal, as does the long\u2010term association between clinical and microbiologic outcomes after such strategies. The aim of this study is to examine the relationship between clinical and microbiologic outcomes of four different treatment strategies for chronic destructive periodontitis among patients who maintain excellent oral hygiene and low gingival bleeding scores.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> One hundred eighty\u2010four patients with periodontitis and capable of maintaining a high standard of oral hygiene were randomly allocated to one of four treatment groups: 1) FDIS + metronidazole; 2) FDIS + placebo; 3) SRP + metronidazole; and 4) SRP + placebo. Recordings of plaque, bleeding on probing, probing depth (PD), and clinical attachment level were carried out in four sites per tooth at baseline, 3 and 12 months after treatment. Before treatment, pooled subgingival samples were obtained from the five deepest pockets, which were sampled again 3 and 12 months after treatment. Microbiologic assessments of eight putative periodontal pathogens were performed using the checkerboard DNA\u2010DNA hybridization method.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Levels of bacterial species were already relatively low at baseline. The only microbial factor statistically significantly associated with the clinical outcomes of treatment after 12 months was the association between reductions of <jats:italic>Tannerella forsythia<\/jats:italic> and being free from PD \u22655 mm.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In this clinical trial, the only microbial factor associated with the clinical outcomes after 12 months was a statistically significant association between the reductions of <jats:italic>T. forsythia<\/jats:italic> and being free from PD \u22655 mm.<\/jats:p>","DOI":"10.1902\/jop.2015.140620","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T05:40:29Z","timestamp":1426138829000},"page":"856-865","source":"Crossref","is-referenced-by-count":26,"title":["Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical 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