{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:20:59Z","timestamp":1783419659247,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold><jats:bold>:<\/jats:bold> The aim of this cross\u2010sectional study is to compare the local and systemic levels of soluble receptor activator of nuclear factor\u2010\u03baB ligand (sRANKL), osteoprotegerin (OPG), a proliferation\u2010inducing ligand (APRIL), B\u2010cell activating factor (BAFF), interleukin (IL)\u20106, and IL\u20108 in biofluids of patients with thalassemia major (TM) with or without gingivitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventy\u2010seven patients are included in this study (TM, n = 29; systemically healthy, n = 48). Gingival crevicular fluid (GCF), saliva, and serum levels of IL\u20106, IL\u20108, sRANKL, OPG, BAFF, and APRIL were determined by enzyme\u2010linked immunosorbent assay. Data were analyzed by appropriate non\u2010parametric or parametric statistical tests.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Median GCF, serum, and saliva levels for BAFF (<jats:italic>P<\/jats:italic> &lt;0.001) and IL\u20106 and IL\u20108 (<jats:italic>P<\/jats:italic> &lt;0.005) were higher in TM gingivitis than in systemically healthy gingivitis (<jats:italic>P<\/jats:italic> &lt;0.001). GCF, serum, and saliva levels for APRIL, sRANKL, IL\u20106, and IL\u20108 were higher in TM than in systemically and periodontally healthy comparison groups (<jats:italic>P<\/jats:italic> &lt;0.05). Positive correlations were found between bleeding on probing (BOP), plaque index (PI) scores, and GCF APRIL, serum sRANKL, serum OPG, and sRANKL concentrations in TM groups (<jats:italic>P<\/jats:italic> &lt;0.05). Several significant positive correlations were found between BOP, PI scores, and biofluid parameters also in systemically healthy groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> TM may have a role in the underlying systemic hematologic condition and potentially affect gingival inflammation via dysregulation of lymphocytes and increased activation of osteoclasts.<\/jats:p>","DOI":"10.1902\/jop.2015.140639","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T05:23:03Z","timestamp":1431494583000},"page":"1047-1057","source":"Crossref","is-referenced-by-count":17,"title":["The Association Between Thalassemia Major and Periodontal Health"],"prefix":"10.1002","volume":"86","author":[{"given":"Aliye","family":"Akcal\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selda","family":"Kahraman 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