{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:33:06Z","timestamp":1773369186214,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> A novel member of the interleukin (IL)\u201012 family, IL\u201035 is an important inhibitory cytokine released by regulatory T cells. The aim of this study is to evaluate gingival crevicular fluid (GCF), saliva, and plasma levels of IL\u201035 in periodontal disease and health.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Samples of GCF, whole saliva, and plasma were obtained from systemically healthy, non\u2010smoking individuals with gingivitis (n = 20) or chronic periodontitis (CP) (n = 20) and periodontally healthy individuals (n = 20). Full\u2010mouth clinical periodontal measurements, including probing depth (PD), bleeding on probing, gingival index, and plaque index (PI), were also recorded. Enzyme\u2010linked immunosorbent assay was used to determine IL\u201035 levels in the samples. Data were tested statistically by analysis of variance and Pearson rank correlation test.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All clinical parameters were significantly higher in the CP group than the healthy and gingivitis groups (<jats:italic>P<\/jats:italic> &lt;0.001). The GCF total amount of IL\u201035 was significantly higher in the CP group than the other groups (<jats:italic>P<\/jats:italic> = 0.04), whereas the GCF concentration of IL\u201035 was significantly higher in the healthy group than the other groups (<jats:italic>P<\/jats:italic> = 0.002). There were significant differences among the study groups in terms of salivary IL\u201035 level (<jats:italic>P<\/jats:italic> &lt;0.001), with the highest level observed in the healthy group and the lowest in the CP group. There was no statistical difference between groups in plasma levels of IL\u201035 (<jats:italic>P<\/jats:italic> &gt;0.05). There was a positive correlation between GCF total amount of IL\u201035 and PD (<jats:italic>r<\/jats:italic> = 0.338, <jats:italic>P<\/jats:italic> = 0.03) and PI (<jats:italic>r<\/jats:italic> = 0.374, <jats:italic>P<\/jats:italic> = 0.005) parameters.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> IL\u201035 could have an important role in suppressing periodontal inflammation and maintaining periodontal health. Additional studies are required to evaluate its role in periodontal diseases.<\/jats:p>","DOI":"10.1902\/jop.2015.140666","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T08:17:29Z","timestamp":1426753049000},"page":"964-971","source":"Crossref","is-referenced-by-count":30,"title":["Level of Interleukin\u201035 in Gingival Crevicular Fluid, Saliva, and Plasma in Periodontal Disease and Health"],"prefix":"10.1002","volume":"86","author":[{"given":"Serhat","family":"K\u00f6seo\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Sa\u011flam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011fba","family":"Pekba\u011fr\u0131yan\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Savran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep","family":"S\u00fct\u00e7\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00193.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060465"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510376402"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00820.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1995.tb00191.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)80606-2"},{"key":"e_1_2_8_8_1","first-page":"723","article-title":"Cell interactions in the induction of tolerance: The role of thymic lymphocytes","volume":"18","author":"Gershon RK","year":"1970","journal-title":"Immunology"},{"key":"e_1_2_8_9_1","first-page":"903","article-title":"Infectious immunological tolerance","volume":"21","author":"Gershon RK","year":"1971","journal-title":"Immunology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00315"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00191"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2366"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200322919"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06306"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1952"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","unstructured":"WhiteheadGS WilsonRH NakanoK BurchLH NakanoH CookDN. 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