{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:29:09Z","timestamp":1787023749979,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Many studies have been conducted to explore the association between interleukin (\n                    <jats:italic>IL)\u20101\u03b2<\/jats:italic>\n                    C\u2010511T polymorphism and risk of chronic periodontitis (CP) but with different or even contradictory results. A meta\u2010analysis was performed to further explore their association.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    PubMed, Chinese National Knowledge Infrastructure, and EMBASE were searched up to September 30, 2014 for relevant case\u2010control studies. Two authors (D\u2010YL and L\u2010YX) independently selected studies and extracted data from included studies. The meta\u2010analysis was performed using comprehensive meta\u2010analysis software.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Nineteen case\u2010control studies involving 2,173 patients with CP and 3,900 healthy controls were included. Using a random\u2010effects meta\u2010analysis model, a non\u2010significant association between\n                    <jats:italic>IL\u20101\u03b2<\/jats:italic>\n                    C\u2010511T polymorphism and CP was identified (T versus C: odds ratio [OR] = 1.03, 95% confidence interval [CI] = 0.85 to 1.25; TT versus CC: OR = 1.03, 95% CI = 0.72 to 1.46; CT versus CC: OR = 0.96, 95% CI = 0.71 to 1.30; CT + TT versus CC: OR = 1.00, 95% CI = 0.74 to 1.34; TT versus CT + CC: OR = 1.05, 95% CI = 0.81 to 1.38), and sensitivity analysis indicated that the results were robust. Subgroup analyses also revealed a non\u2010significant association. No publication bias was detected.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Based on currently available evidence,\n                    <jats:italic>IL\u20101\u03b2<\/jats:italic>\n                    C\u2010511T polymorphism is not associated with the risk of developing CP. Additional research is warranted to further explore and confirm the association of genetic polymorphism and CP.\n                  <\/jats:p>","DOI":"10.1902\/jop.2015.140698","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T10:20:32Z","timestamp":1425550832000},"page":"812-819","source":"Crossref","is-referenced-by-count":38,"title":["Meta\u2010Analysis of Association Between Interleukin\u20101\u03b2 C\u2010511T Polymorphism and Chronic Periodontitis Susceptibility"],"prefix":"10.1002","volume":"86","author":[{"given":"Xian\u2010Tao","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey S. 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