{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:56:33Z","timestamp":1788900993977,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004061","name":"Oesterreichische Nationalbank","doi-asserted-by":"publisher","award":["ONB 14152"],"award-info":[{"award-number":["ONB 14152"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study aims to investigate calcium\u2010binding myeloid\u2010related protein (MRP)\u20108\/14 in the saliva and serum of individuals with periodontitis and periodontally healthy individuals for the assessment of its role in the pathogenesis and clinical diagnosis of periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This cross\u2010sectional study includes 56 patients with periodontitis and 44 periodontally healthy individuals. Saliva and serum were collected for the detection of MRP\u20108\/14 and calcium levels. Periodontopathic bacteria were determined by polymerase chain reaction in saliva. Correlations between salivary and serum MRP\u20108\/14 levels and clinical parameters, bacteria, and calcium were analyzed with Pearson correlation in a multiple regression model. MRP\u20108\/14 levels were documented with receiver operating characteristic (ROC) curves.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Compared with healthy individuals, MRP\u20108\/14 levels were significantly higher in both the saliva and serum of patients with periodontitis, but calcium was increased only in saliva. A high diagnostic potential of salivary MRP\u20108\/14 was detected for periodontitis (ROC = 0.86). Salivary MRP\u20108\/14 levels correlated significantly with the presence of the periodontopathogen <jats:italic>Treponema denticola<\/jats:italic>, as well as with the clinical parameters of periodontitis.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> MRP\u20108\/14 in saliva might be a potential diagnostic parameter for periodontal disease.<\/jats:p>","DOI":"10.1902\/jop.2015.150254","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T13:28:42Z","timestamp":1444310922000},"page":"184-192","source":"Crossref","is-referenced-by-count":53,"title":["Comparative Analysis of Calcium\u2010Binding Myeloid\u2010Related Protein\u20108\/14 in Saliva and Serum of Patients With Periodontitis and Healthy 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