{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:14:26Z","timestamp":1792793666978,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004048","name":"Kashan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> MicroRNAs (miRNAs) are a group of small non\u2010coding RNAs that play an important role in the regulation of gene expression. miRNA\u2010146a (miR\u2010146a), a member of the miR\u2010146 family, is involved in the control of inflammation. Periodontitis is a set of chronic inflammatory disorders of the tissues surrounding the teeth that lead to the breakdown of alveolar bone and tooth loss. In this study, expression levels of miR\u2010146a and its targets, including tumor necrosis factor (TNF)\u2010\u03b1, interleukin (IL)\u20101\u03b2, and IL\u20106, are evaluated in human patients with chronic periodontitis (CP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study population consisted of 10 healthy controls and 20 individuals with CP. For each participant, clinical parameters including probing depth and clinical attachment level were measured, and a gingival tissue sample was collected. Levels of miR\u2010146a, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 were quantified using real\u2010time polymerase chain reaction.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Levels of miR\u2010146a were significantly higher in patients with CP (<jats:italic>P<\/jats:italic> &lt;0.001). There was a positive correlation between levels of miR\u2010146a and clinical parameters (<jats:italic>P<\/jats:italic> &lt;0.05). Elevated miR\u2010146a was accompanied by a significant reduction in TNF\u2010\u03b1 and IL\u20106 (<jats:italic>P<\/jats:italic> &lt;0.001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Patients with CP had higher levels of miR\u2010146a than healthy individuals, accompanied by reduced levels of TNF\u2010\u03b1 and IL\u20106. A positive relationship between miR\u2010146a levels and clinical parameters suggests a pathophysiologic role of miR\u2010146a in CP.<\/jats:p>","DOI":"10.1902\/jop.2015.150319","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T10:34:44Z","timestamp":1440671684000},"page":"1380-1385","source":"Crossref","is-referenced-by-count":88,"title":["Evaluation of MicroRNA\u2010146a and Its Targets in Gingival Tissues of Patients With Chronic 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