{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:13:39Z","timestamp":1780528419311,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Periodontitis is a biofilm\u2010initiated disease that is characterized by elevated inflammatory status. 8\u2010Hydroxydeoxyguanosine (8\u2010OHdG) and interleukin (IL)\u201017 are highly associated with inflammation and bone resorption and therefore are regarded as potential biomarkers for periodontitis. In this study, the associations between salivary 8\u2010OHdG and IL\u201017 levels and clinical and microbial parameters before and after non\u2010surgical treatment are investigated.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010five patients with chronic periodontitis (CP) and 47 periodontally healthy volunteers were recruited for the study. Clinical parameters, including the probing depth (PD), clinical attachment level (CAL), sulcular bleeding index, and simplified oral hygiene index (OHI\u2010S), were examined for each participant. Microbial parameters including the quantities of <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic>, and <jats:italic>Treponema denticola<\/jats:italic> in the subgingival plaque and saliva were determined by real\u2010time polymerase chain reaction at baseline and 1 and 3 months after the non\u2010surgical treatment. Salivary 8\u2010OHdG and IL\u201017 levels were detected by enzyme\u2010linked immunosorbent assays.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Compared with healthy volunteers, CP group patients had significantly higher salivary 8\u2010OHdG and IL\u201017 levels at baseline. Baseline salivary 8\u2010OHdG and IL\u201017 levels were positively correlated with all clinical parameters as well as the quantities of <jats:italic>T<\/jats:italic>. <jats:italic>forsythia<\/jats:italic> and <jats:italic>T. denticola<\/jats:italic>. After non\u2010surgical treatment, baseline levels of salivary 8\u2010OHdG and IL\u201017 were reduced significantly at both the 1\u2010 and 3\u2010month follow\u2010ups. The hierarchical linear model revealed that variations in the PD, CAL, and OHI\u2010S had significant positive effects on variation in the salivary 8\u2010OHdG level. However, variations in the PD; quantity of <jats:italic>T<\/jats:italic>. <jats:italic>forsythia<\/jats:italic> in the subgingival plaque; and quantities of <jats:italic>P<\/jats:italic>. <jats:italic>gingivalis<\/jats:italic>, <jats:italic>T<\/jats:italic>. <jats:italic>forsythia<\/jats:italic>, and <jats:italic>T<\/jats:italic>. <jats:italic>denticola<\/jats:italic> in saliva were associated significantly with variation in the salivary IL\u201017 levels.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> There was a strong association between salivary 8\u2010OHdG and IL\u201017 levels and periodontitis. Variation in the salivary 8\u2010OHdG level was correlated with variations in the clinical parameters, whereas variation in the IL\u201017 level was correlated with variation in the microbial parameters.<\/jats:p>","DOI":"10.1902\/jop.2015.150390","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T07:05:53Z","timestamp":1450076753000},"page":"591-600","source":"Crossref","is-referenced-by-count":30,"title":["The Influences of Periodontal Status and Periodontal Pathogen Quantity on Salivary 8\u2010Hydroxydeoxyguanosine and Interleukin\u201017 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