{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:22:50Z","timestamp":1781108570066,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this systematic review is to evaluate the effects of platelet\u2010rich fibrin (PRF) membranes on the outcomes of clinical treatments in patients with gingival recession.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Articles that were published before June 2015 were searched electronically in four databases without any date or language restrictions and searched manually in regular journals and unpublished studies. The eligibility criteria comprised randomized controlled trials (RCTs) and prospective controlled trials with follow\u2010up periods of \u22656 months that compared the performance of PRF to other biomaterials in the treatment of Miller Class I or II gingival recessions. For the meta\u2010analysis, the inverse variance method was used in fixed\u2010 or random\u2010effect models, which were chosen according to heterogeneity. The estimates of the intervention effects were expressed as the mean differences in percentages or millimeters.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Six RCTs and one prospective clinical trial are included in this review. Root coverage (RC) and clinical attachment level (CAL) did not differ significantly between the analyzed subgroups (<jats:italic>P<\/jats:italic> = 0.57 and <jats:italic>P<\/jats:italic> = 0.50, respectively). The keratinized mucosa width (KMW) gain was significantly greater (<jats:italic>P<\/jats:italic> = 0.04) in the subgroup that was treated with connective tissue grafts.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The results of the meta\u2010analysis suggest that the use of PRF membranes did not improve the RC, KMW, or CAL of Miller Class I and II gingival recessions compared with the other treatment modalities.<\/jats:p>","DOI":"10.1902\/jop.2015.150420","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T12:04:26Z","timestamp":1447329866000},"page":"281-290","source":"Crossref","is-referenced-by-count":70,"title":["Use of Platelet\u2010Rich Fibrin Membrane in the Treatment of Gingival Recession: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"87","author":[{"given":"Vittorio","family":"Moraschini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane dos Santos Porto","family":"Barboza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.6.489"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2003.0137"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12330"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060277"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080253"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.11.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12185"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01492.x"},{"key":"e_1_2_7_10_1","first-page":"395","article-title":"Tunneling procedure for root coverage using acellular dermal matrix: A case series","volume":"29","author":"Modaressi M","year":"2009","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_11_1","first-page":"729","article-title":"Using platelet\u2010rich plasma to accelerate soft tissue maturation in esthetic periodontal surgery","volume":"22","author":"Petrungaro PS","year":"2001","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.10.1768"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130513.x"},{"key":"e_1_2_7_14_1","first-page":"121","article-title":"The influence of platelet\u2010rich plasma on the healing of extraction sockets: An explorative randomised clinical trial","volume":"3","author":"Alissa R","year":"2010","journal-title":"Eur J Oral Implantology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.21.7696"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112800624391"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112800624382"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190802636713"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.05.048"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090531"},{"key":"e_1_2_7_22_1","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 [updated March 2011].The Cochrane Collaboration 2011. 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