{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:55:42Z","timestamp":1772661342659,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Recent consensus emphasizes the importance of studying individuals at risk for rheumatoid arthritis (pre\u2010RA) and those with early RA (eRA). Periodontal tissues have been recently evaluated, but these studies are limited. To evaluate the periodontal condition, immunoglobulin (Ig)G subclasses against <jats:italic>Porphyromonas gingivalis<\/jats:italic> in individuals with pre\u2010RA and eRA were compared with controls to establish an association between periodontal infection markers and rheumatic activity.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Rheumatologic and periodontal condition was evaluated in 119 individuals with pre\u2010RA, 48 patients with eRA, and matched controls. <jats:italic>P. gingivalis<\/jats:italic> IgG1 and IgG2 were analyzed. C\u2010reactive protein, erythrocyte sedimentation rate (ESR), rheumatoid factor, anticitrullinated protein antibodies (ACPAs), and RA activity were measured. The groups were compared with McNemar test and paired <jats:italic>t<\/jats:italic>\u2010test. Conditional logistic regression was performed for pre\u2010RA confounders, and \u03c7<jats:sup>2<\/jats:sup> test was used to evaluate periodontal variables and RA activity indices.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Pre\u2010RA individuals showed significantly higher levels of plaque index (<jats:italic>P<\/jats:italic> = 0.01) and bleeding on probing (<jats:italic>P<\/jats:italic> = 0.03) and higher severity of periodontal disease (<jats:italic>P<\/jats:italic> = 0.02). Periodontitis was associated with pre\u2010RA (odds ratio, 3.39; 95% confidence interval, 1.64 to 7.01) but not with eRA. In pre\u2010RA, <jats:italic>P. gingivalis<\/jats:italic>\u2013specific IgG2 was associated with ACPAs (<jats:italic>P<\/jats:italic> = 0.049) and disease severity visual analog scale (<jats:italic>P<\/jats:italic> = 0.03). In eRA, IgG2 against <jats:italic>P. gingivalis<\/jats:italic> was associated with ESR (<jats:italic>P<\/jats:italic> = 0.046) and ACPAs (<jats:italic>P<\/jats:italic> = 0.04). <jats:italic>P. gingivalis<\/jats:italic> was associated with ACPAs (<jats:italic>P<\/jats:italic> = 0.04).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This study shows that individuals with pre\u2010RA have significant inflammatory periodontal involvement. There was a significant association between IgG against <jats:italic>P. gingivalis<\/jats:italic> and ACPAs in pre\u2010RA and markers of RA activity in individuals with eRA.<\/jats:p>","DOI":"10.1902\/jop.2015.150455","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T08:42:51Z","timestamp":1448527371000},"page":"346-356","source":"Crossref","is-referenced-by-count":76,"title":["Periodontal Disease in Individuals With a Genetic Risk of Developing Arthritis and Early Rheumatoid Arthritis: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"87","author":[{"given":"Juan M.","family":"Bello\u2010Gualtero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria I.","family":"Lafaurie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida 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