{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:54:36Z","timestamp":1791888876615,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of the present study is to evaluate the serum receptor activator of nuclear factor\u2010\u03ba\u03b2 ligand (RANKL)\/osteoprotegerin (OPG) system in patients with chronic periodontitis (CP) and type 2 diabetes mellitus (T2DM) and its changes after periodontal intervention.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010five patients with CP + T2DM, 35 systemically healthy patients with CP, and 35 healthy controls were enrolled, and serum levels of RANKL and OPG were measured at baseline. Then the CP + T2DM group was divided into a well\u2010controlled subgroup and a poorly controlled subgroup according to their hemoglobin A1c (HbA1c), and initial periodontal therapy was performed. After 3 months, patients in both subgroups were recalled, and serum RANKL and OPG levels were tested again and compared with the baseline.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At baseline, serum levels of OPG in the T2DM + CP group were much lower than in the CP group and healthy controls (197.41 \u00b1 57.05 pg\/mL versus 232.60 \u00b1 70.85 pg\/mL [CP group] or 244.96 \u00b1 85.13 pg\/mL [healthy controls], <jats:italic>P<\/jats:italic> &lt;0.05), whereas their RANKL levels were much higher than in the other two groups (324.35 \u00b1 87.62 pg\/mL versus 284.52 \u00b1 90.35 pg\/mL [CP group] or 163.01 \u00b1 45.24 pg\/mL [healthy control], <jats:italic>P<\/jats:italic> &lt;0.05), as was the RANKL\/OPG (R\/O) ratio (1.68 \u00b1 0.33 versus 1.26 \u00b1 0.35 [CP group] or 0.72 \u00b1 0.25 [healthy control], <jats:italic>P<\/jats:italic> &lt;0.001). Serum levels of OPG in both disease groups had significant negative correlations with HbA1C, and serum levels of RANKL in all participants had significant positive correlations with periodontal parameters. After periodontal intervention, both the well\u2010controlled and poorly controlled subgroups exhibited significant increases in OPG and decreases in RANKL in serum, and the R\/O ratio was also notably reduced. Additionally, the poorly controlled subgroup exhibited a greater reduction in HbA1c and a greater increase in OPG than the well\u2010controlled subgroup.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The changing trend in the serum RANKL\/OPG system in patients with T2DM + CP was similar to that seen in CP patients and may be even more pronounced. Periodontal intervention effectively improved glucose metabolism and changed the serum RANKL\/OPG system regardless of whether patients\u2019 HbA1c was well\u2010controlled or poorly controlled over the 3\u2010month observation period.<\/jats:p>","DOI":"10.1902\/jop.2015.150480","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T12:04:26Z","timestamp":1447329866000},"page":"303-311","source":"Crossref","is-referenced-by-count":12,"title":["The Effects of Initial Periodontal Therapy on the Serum Receptor Activator of Nuclear Factor\u2010\u03ba\u03b2 Ligand\/Osteoprotegerin System in Patients With Type 2 Diabetes Mellitus and Periodontitis"],"prefix":"10.1002","volume":"87","author":[{"given":"Jing Ling","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan Xin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian E.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01678.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01032.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120255"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-18-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00934.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060398"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2033"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81569-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/36593"},{"issue":"4","key":"e_1_2_7_11_1","first-page":"S113","article-title":"A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes","volume":"84","author":"Taylor JJ","year":"2013","journal-title":"J Periodontol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00347.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130356"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01810.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711797535281"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3348-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.09.019"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060398"},{"key":"e_1_2_7_20_1","first-page":"221","article-title":"Relationships between osteoprotegerin, receptor activator of the nuclear factor kB ligand and serum levels and carotid intima\u2010media thickness in patients with type 2 diabetes mellitus","volume":"56","author":"Gaudio A","year":"2014","journal-title":"Panminerva Med"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"issue":"2","key":"e_1_2_7_22_1","first-page":"B5","article-title":"Type 2 diabetes worldwide according to the new classification and criteria","volume":"23","author":"Shaw JE","year":"2000","journal-title":"Diabetes Care"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02031.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01440.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140444"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1085425"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.10.001"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.09.003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100125"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01701.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110324"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2015.150480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:36:14Z","timestamp":1760873774000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2015.150480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1902\/jop.2015.150480"],"URL":"https:\/\/doi.org\/10.1902\/jop.2015.150480","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]}}}