{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:57:31Z","timestamp":1777402651058,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The present study was designed to evaluate effectiveness of 1.2% atorvastatin (ATV) gel, as an adjunct to scaling and root planing (SRP) in the treatment of intrabony defects in chronic periodontitis (CP) in patients with type 2 diabetes mellitus (t2DM).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventy\u2010five patients were categorized into two treatment groups: 1) SRP plus 1.2% ATV and 2) SRP plus placebo. Clinical parameters including modified sulcus bleeding index, probing depth (PD), and relative attachment level (RAL) were recorded at baseline and 3, 6, and 9 months. Percentage radiographic defect depth reduction was evaluated using computer\u2010aided software at baseline and 6 and 9 months.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Mean PD reduction and mean RAL gain was greater in the ATV group than the placebo group at 3, 6, and 9 months. Furthermore, ATV group sites presented with a significantly greater percentage of radiographic defect depth reduction at 6 and 9 months.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Locally delivered ATV was found to be effective in treatment of intrabony defects in CP in patients with t2DM.<\/jats:p>","DOI":"10.1902\/jop.2016.130227","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T10:56:24Z","timestamp":1469098584000},"page":"1278-1285","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy of Subgingivally Delivered 1.2% Atorvastatin in the Treatment of Chronic Periodontitis in Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial"],"prefix":"10.1002","volume":"87","author":[{"given":"Minal","family":"Kumari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh 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