{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:14:07Z","timestamp":1793146447637,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271137"],"award-info":[{"award-number":["81271137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470742"],"award-info":[{"award-number":["81470742"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study aims to evaluate the performance of chitosan\/anorganic bovine bone (C\/ABB) scaffold seeded with human jaw bone marrow\u2010derived mesenchymal stem cells (hJBMMSCs) in supporting the healing\/repair of 1\u2010wall critical\u2010size periodontal defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Physical properties of the C\/ABB scaffold were compared with those of the chitosan scaffold. hJBMMSCs were obtained from healthy human alveolar bone during the extraction of third molar impacted teeth. One\u2010wall (7 \u00d7 4 mm) infrabony defects were surgically created at the bilateral mandibular third premolars and first molars in six beagles. The defects were randomly assigned to six groups and implanted with different scaffolds: 1) chitosan (C) scaffold; 2) C scaffold with hJBMMSCs (C + cell); 3) C\/ABB scaffold (C\/ABB); 4) C\/ABB scaffold with hJBMMSCs (C\/ABB + cell); 5) ABB scaffold (ABB); and 6) open flap debridement (control). The animals were euthanized 8 weeks after surgery for histologic analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The C\/ABB scaffold had a porous structure and increased compressive strength. Both C\/ABB and C\/ABB + cell exhibited the newly formed cellular mixed\u2010fiber cementum, woven\/lamellar bone, and periodontal ligament. Cementum formation was significantly greater in group C\/ABB + cell than in group C\/ABB (2.64 \u00b1 0.50 mm versus 0.91 \u00b1 0.55 mm, <jats:italic>P<\/jats:italic> &lt;0.05). For new bone (NB) height, group C\/ABB + cell and C\/ABB showed mean \u00b1 SD values of 2.83 \u00b1 0.29 mm and 2.65 \u00b1 0.52 mm and for NB area 8.89 \u00b1 1.65 mm and 8.73 \u00b1 1.94 mm<jats:sup>2<\/jats:sup>, respectively. For NB (height and area), there was no significant difference between the two groups.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The combination of hJBMMSCs and C\/ABB scaffolds could promote periodontal repair. Future studies are expected to further optimize the combination and lead to an ideal periodontal regeneration.<\/jats:p>","DOI":"10.1902\/jop.2016.150504","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T09:24:11Z","timestamp":1462526651000},"page":"971-981","source":"Crossref","is-referenced-by-count":28,"title":["Periodontal Wound Healing by Transplantation of Jaw Bone Marrow\u2010Derived Mesenchymal Stem Cells in Chitosan\/Anorganic Bovine Bone Carrier Into One\u2010Wall Infrabony Defects in 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