{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:00:22Z","timestamp":1773788422802,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Little is known regarding associations of periodontitis with diseases of the nose, one of the structures adjacent to the mouth. This study aims to explore the association between periodontitis and previous allergic rhinitis (AR) using a matched patient\u2013control study design from a population\u2010based dataset in Taiwan.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Data were sourced from the Longitudinal Health Insurance Database 2000 for 71,182 patients with chronic periodontitis (CP) and 71,182 controls without periodontitis. Generalized linear mixed\u2010model analyses were used to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for previous AR diagnosis in patients and controls.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Significant difference was found in prevalence of prior AR for patients and controls (28.4% versus 24.2%; <jats:italic>P<\/jats:italic> &lt;0.001). Generalized linear mixed model suggested that the OR of previous AR for patients was 1.24 (95% CI: 1.22 to 1.27; <jats:italic>P<\/jats:italic> &lt;0.001) compared with controls. Adjustments were made for: 1) monthly income; 2) urbanization level; 3) diabetes mellitus; 4) hypertension; 5) coronary heart disease; 6) hyperlipidemia; 7) alcohol abuse; 8) tobacco use disorder; and 9) random effect of geographic region. After adjusting, OR of previous AR diagnosis among patients was 1.21 (95% CI: 1.18 to 1.23; <jats:italic>P<\/jats:italic> &lt;0.001) compared with controls.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> An association between periodontitis and prior AR is demonstrated. It is recommended that physicians be more alert for potential risk of subsequent development of CP in patients with AR.<\/jats:p>","DOI":"10.1902\/jop.2016.150539","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T08:58:53Z","timestamp":1459760333000},"page":"749-755","source":"Crossref","is-referenced-by-count":19,"title":["Allergic Rhinitis Is Associated With Periodontitis: A Population\u2010Based Study"],"prefix":"10.1002","volume":"87","author":[{"given":"Shih\u2010Han","family":"Hung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Chieh","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herng\u2010Ching","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiu\u2010Dong","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.727-752.2001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.8.1406"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-3382(12)70006-4"},{"key":"e_1_2_7_6_1","first-page":"3","article-title":"Risk factors for periodontitis","volume":"7","author":"Van Dyke TE","year":"2005","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115569"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.003"},{"key":"e_1_2_7_9_1","first-page":"556","article-title":"Prevalence, severity, and time trends of allergic conditions in 6\u2010to\u20107\u2010year\u2010old schoolchildren in Taipei","volume":"21","author":"Wu WF","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0963"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4060"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24532"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0097-0522(34)90147-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809125100"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-010-0289-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2087"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.116178"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130807"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000553"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23720"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(87)90328-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21120"},{"key":"e_1_2_7_23_1","first-page":"S11","article-title":"Comorbidities and allergic rhinitis: Not just a runny nose","volume":"61","author":"Hadley JA","year":"2012","journal-title":"J Fam Pract"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24532"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70126-X"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115562"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3145-9"},{"key":"e_1_2_7_28_1","first-page":"913","article-title":"The expression of serum IL\u201010,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis (in Chinese)","volume":"21","author":"Chen J","year":"2007","journal-title":"J Clin Otorhinolaryngol Head Neck Surg"},{"key":"e_1_2_7_29_1","first-page":"31","article-title":"Interleukin 16 (IL\u201016) in asthma and allergic rhinitis. 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